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| Description | Hexapeptide-9, trade name Collaxyl, is a synthetic hexapeptide composed of repeating glycine, proline, and glutamine, with sequence Gly-Pro-Gln-Gly-Pro-Gln (GPQGPQ). As a biomimetic peptide of the proline-rich domain of collagen, GPQGPQ mimics the characteristic structure of the Gly-Pro-X repeating sequence in collagen and is recognized by skin fibroblasts, modulating TGF-β/Smad and MAPK signaling pathways to promote the synthesis of type I and IV collagen and fibronectin, enhancing dermal and basement membrane structural support, and promoting skin repair and regeneration. Studies demonstrate that it improves skin elasticity and firmness, reduces wrinkles, and promotes wound healing and skin barrier repair. With a small molecular weight (583 Da) and good water solubility, it is easy to incorporate into formulations. Widely used in anti-aging, anti-wrinkle, skin repair, and barrier repair skincare formulation development, and cosmetic mechanism research. |
| Peptide purity (HPLC) | ≥98% |
| Molecular formula | C₂₄H₃₈N₈O₉ |
| Molecular weight (Da) | 582.61 |
| Structure type | Linear hexapeptide, collagen-derived peptide, rich in proline and glycine, free peptide |
| Solubility | Freely water-soluble, no co-solvent required |
| Storage | Sealed, below 25 °C, cool and dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Hexapeptide-9 | Hexapeptide-9; collagen-activating hexapeptide; anti-aging repair hexapeptide | Anti-aging repair peptide, collagen & elastin synthesis promotion, fibroblast activation, dermal matrix remodeling | Collagen homologous linear functional hexapeptide retains the core active epitope structure of collagen, directly activates fibroblast matrix synthesis signaling pathway | C₃₀H₅₂N₈O₈ | 652.39 | ~652.8 | Acetate | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-HEP009 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Acetate salt is freely soluble in water, dilute acetic acid and polyol systems. Stable under acidic to neutral conditions; elevated risk of side chain degradation under alkaline conditions. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-HEP009 | Hexapeptide-9, collagen homologous peptide, activates fibroblasts to synchronously boost collagen & elastin | Hexapeptide-9 is a collagen homologous functional active hexapeptide, retaining the core active epitope structure of collagen. It directly acts on dermal fibroblasts to activate matrix synthesis signaling pathways, synchronously upregulates the biosynthesis of type Ⅰ collagen, type Ⅲ collagen and elastin, improves the structural integrity and elasticity of the dermal matrix, and effectively ameliorates skin laxity and reduces static fine lines. It also promotes laminin synthesis to strengthen the dermal-epidermal junction and enhance overall skin firmness. | Skin anti-aging research, fibroblast function study, elastin regulation study, dermal matrix repair, anti-aging skincare development | Fibroblast activation pathway; collagen-elastin synthesis regulatory pathway; laminin expression pathway |
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