Cell interaction peptides are sequence-defined ligands that mimic the natural “sticky” motifs of extracellular matrix and cell-surface receptors — enabling defined cell adhesion, integrin / cadherin engagement, controlled 3D encapsulation, and growth-factor binding for tissue engineering, regenerative medicine, and cell-delivery research.
3–30 aa · linear, cyclic or self-assembling
Integrins · cadherins · HSPG · selectins
Surface · hydrogel · multi-domain · GF-coupled
What Are Cell Interaction Peptides
Short amino-acid sequences (3–30 aa) derived from extracellular-matrix proteins, cadherin ectodomains, or surface receptors that drive defined cell–matrix and cell–cell engagement. They are widely used as defined building blocks for 2D surface coating, 3D encapsulation hydrogels, and targeted cell-delivery carriers.
Adhesion Motifs & Receptors
Mature motifs cover RGD-type integrin engagement, HAV-based N-cadherin binding, IKVAV / YIGSR from laminin, REDV / LDV from fibronectin, and DGEA / GFOGER from collagen. Each motif pairs with a specific integrin or cadherin family member, allowing cell-type-selective adhesion design.
Application Formats
Supplied as 2D surface-grafted monolayers, self-assembling 3D hydrogels (RAD16-I/II, MAX1, MAX8, KLD), biotin / maleimide / click-ready conjugates, or multi-domain constructs (RGD–PHSRN, RGD–HBD). All formats are endotoxin-controlled, sterile-filterable, and qualified for in-vitro / in-vivo cell work.
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![Arg-Gly-Asp-Ser (RGDS)]()
Arg-Gly-Asp-Ser (RGDS)Product Name：Arg-Gly-Asp-Ser (RGDS)CAS No.：91037-65-9Sequence：Arg-Gly-Asp-Ser (RGDS)Length：4 amino acidsMolecular Formula：C15H27N7O8Molecular Weight：433.42 DaOrigin：Synthetic (fibronectin -
![Arg-Gly-Asp (RGD)]()
Arg-Gly-Asp (RGD)Product Name：H-Arg-Gly-Asp-OH (Arg-Gly-Asp, RGD)CAS No.：99896-85-2Sequence：Arg-Gly-Asp (RGD)Length：3 amino acidsMolecular Formula：C12H22N6O6Molecular Weight：346.34 DaOrigin：Synthetic (minimal -
![Laminin (925-933) (TFA)]()
Laminin (925-933) (TFA)Product Name：Laminin (925-933)(TFA) (CDPGYIGSR)CAS No. (free base)：110590-60-8CAS No. (TFA salt)：2828432-44-4Sequence：Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg (CDPGYIGSR)Length：9 amino acidsMolecular -
![Collagen Binding Peptide (fibronectin Collagen-binding Fragment)]()
Collagen Binding Peptide (fibronectin Collagen-binding Fr...Product Name: Collagen binding peptide (Collagen-Binding Fragment); CAS No.: 94040-53-6; Sequence: Cys-Gln-Asp-Ser-Glu-Thr-Arg-Thr-Phe-Tyr (CQDSETRTFY); Length: 10 amino acids; Molecular Formula: -
![RGD Peptide (GRGDNP), TFA Salt]()
RGD Peptide (GRGDNP), TFA SaltProduct Name: RGD peptide (GRGDNP) (TFA); Sequence: Gly-Arg-Gly-Asp-Asn-Pro (GRGDNP); Length: 6 amino acids; Molecular Formula (free base): C₂₃H₃₈N₁₀O₁₀; Molecular Weight (free base): 614.62 Da; -
![RGD Peptide (GRGDNP), Free Base]()
RGD Peptide (GRGDNP), Free BaseProduct Name: RGD peptide (GRGDNP); Sequence: Gly-Arg-Gly-Asp-Asn-Pro (GRGDNP); Length: 6 amino acids; Molecular Formula: C₂₃H₃₈N₁₀O₁₀; Molecular Weight: 614.62 Da; Origin: Synthetic (RGD -
![Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), Extended RGD Hexapeptide, Free Base]()
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), Extended RGD Hexapeptid...Product Name: GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro); CAS No.: 91037-75-1; Sequence: Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP); Length: 6 amino acids; Molecular Formula: C₂₂H₃₇N₉O₁₀; Molecular Weight: 587.58 Da; -
![Arg-Gly-Asp (RGD), Minimal RGD Integrin-recognition Motif Tripeptide, Trifluoroacetate (TFA) Salt]()
Arg-Gly-Asp (RGD), Minimal RGD Integrin-recognition Motif...Product Name: RGD Trifluoroacetate (Arg-Gly-Asp TFA salt); CAS No.: 2378808-45-6; Sequence: Arg-Gly-Asp (RGD); Length: 3 amino acids; Molecular Formula (TFA salt): C₁₄H₂₃F₃N₆O₈; Molecular Weight (TFA -
![H-Ile-Lys-Val-Ala-Val-OH (IKVAV), Laminin α1-chain-derived Neurite-active Pentapeptide, Free Base]()
H-Ile-Lys-Val-Ala-Val-OH (IKVAV), Laminin α1-chain-derive...Product Name: H-Ile-Lys-Val-Ala-Val-OH (IKVAV, laminin-derived peptide); CAS No.: 131167-89-0; Sequence: Ile-Lys-Val-Ala-Val (IKVAV); Length: 5 amino acids; Molecular Formula: C₂₅H₄₈N₆O₆; Molecular -
![Gly-Arg-Gly-Asp-Ser (GRGDS), Classic RGD-core Pentapeptide, Free Base]()
Gly-Arg-Gly-Asp-Ser (GRGDS), Classic RGD-core Pentapeptid...Product Name: Gly-Arg-Gly-Asp-Ser (GRGDS, fibronectin active fragment); CAS No.: 96426-21-0; Sequence: Gly-Arg-Gly-Asp-Ser (GRGDS); Length: 5 amino acids; Molecular Formula: C₁₇H₃₀N₈O₉; Molecular -
![Obtustatin Triacetate]()
Obtustatin TriacetateProduct Name: Obtustatin triacetate; Sequence: 41-residue non-RGD disintegrin; Length: 41 amino acids; Molecular Formula (triacetate complex): C₁₈₄H₂₈₄N₅₂O₅₇S₈·3C₂H₄O₂; Molecular Weight (triacetate -
![GRGDSP TFA (Gly-Arg-Gly-Asp-Ser-Pro TFA Salt)]()
GRGDSP TFA (Gly-Arg-Gly-Asp-Ser-Pro TFA Salt)Product Name: GRGDSP TFA (Gly-Arg-Gly-Asp-Ser-Pro TFA salt); CAS No. (free base): 91037-75-1; Sequence: Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP); Length: 6 amino acids; Molecular Formula (free base):
Cell Interaction Peptides — Frequently Asked Questions
Which integrin does an RGD-like motif actually hit?
Linear GRGDSP / RGD-4C are “promiscuous” RGDs engaging αvβ3, αvβ5 and α5β1; cRGDfK / cRGDyK is selective for αvβ3 (10–100× gain); REDV targets α4β1; LDV targets α4β1; GFOGER is a α1β1 / α2β1 collagen-receptor agonist. Pair PHSRN synergy sequence with RGD for α5β1-specific fibronectin-like adhesion.
Why cyclic RGD, and which closure chemistry?
Head-to-tail lactam or disulfide cyclization (Cys–Cys, Pen–Pen) locks RGD in the ηRGD-bound conformation, raising integrin affinity and serum stability (t½ from <30 min to several hours). Knottin (Cys 1–4, 2–5) and SFTI-1 scaffolds are alternative frames; in-vivo imaging and tumor-targeting builds frequently start from cRGDfK / cRGDyK.
Which cadherin / Ig-CAM motifs control homophilic vs heterophilic binding?
HAV (His-Ala-Val) is the conserved N-cadherin EC1 motif; linear HAVDI / HAVDIG is widely used as a N-cadherin antagonist. E-cadherin uses the related DAD motif. Ig-CAMs (NCAM, ICAM, L1-CAM) use different homophilic interfaces and need ectodomain fragments. Homophilic / heterophilic preference, force dependence, and calcium requirement should be characterized in the customer’s own cell-pair assay.
How do self-assembling peptide hydrogels work for 3D cell culture?
RAD16-I / RAD16-II (Ac-RARADADA-CNH2) form ionic-complementarity β-sheet nanofibers at physiological pH / ionic strength. MAX1 / MAX8 are pH-triggered β-hairpin peptides that gel within minutes upon pH 7.4 shift. KLD-12 and FEFEFKFK give tunable stiffness; functional motifs (RGD, IKVAV, YIGSR) are co-assembled or covalently coupled to drive cell-specific behavior in 3D.
Can heparin-binding peptides carry growth factors?
Yes. FHRRIKA, KRSR and Cardin–Weintraub consensus (XBBXBX / XBBBXXBX, B = basic) bind heparan sulfate proteoglycans and sequester FGF-2, VEGF, BMP-2 via the same domain. Multi-domain constructs (RGD + HBD + MMP-sensitive linker) give simultaneous cell adhesion, growth-factor presentation, and enzymatically triggered release — useful in regenerative-medicine scaffolds.
How are these peptides sterilized and freed from TFA for cell work?
Standard work-up removes TFA by EtOH / HCl precipitation or dialysis (HCl counter-ion on request). Endotoxin is held ≤0.1 EU/mg via LAL QC; sterile filtration is done at 0.22 µm on aqueous, low-viscosity solutions. Cytotoxicity is checked on NHDF, HepG2 and hMSC at working dose; functional adhesion / encapsulation assays are run after each sterilization step.
Shanghai Sonyt Biotechnology Co., Ltd. is one of the most reliable cell interaction peptides manufacturers and suppliers in China. With abundant experience, we warmly welcome you to wholesale custom made cell interaction peptides from our factory. If you have any enquiry about cooperation, please feel free to email us.
