Peptide Modification Services
Peptide modification changes the physical and chemical properties of the peptide by modifying the main chain and side chain structure of the peptide, thereby improving its bioavailability. Modified peptide drugs can significantly reduce immunogenicity, reduce toxic effects, increase water solubility, prolong the action time in the body, and change the distribution in the body. Common peptide modifications include: C-end modification, N-terminal modification, intermediate residue modification, and cyclization modification.
15
Modification Categories
414+
Catalogued Options
Lab
Custom Designs Evaluated
QC
HPLC & MS Verified
Full Modification Portfolio
15 Categories, One Reliable Partner
From terminal capping and cyclization to fluorescent labeling and unnatural residues - explore the complete catalogue below.
01
N-End Modification
32 OPTIONSAcetylation and functional caps at the peptide N-terminus to tune stability, charge, and receptor binding.
AcAllylCholesteryl-N-Propargylglycine-FmocAcrylFructose-AdCBZAllocGlucose-BPS-BocPyrDMAP-AcMorpholine-4-carbonyl-BzD-PyrNTriAcTrans-CinnamoylBz (5-NH2,2-NO2)LA-PhAc2-FuroylBz (4-F)Mpa-Py-AcMethacryl-Bz (4-NO2)TosN-AmidinoglycineBPA-
02
C-End Modification
12 OPTIONSC-terminal variants controlling amidation, esterification, and chromogenic/fluorogenic release groups.
-pNA-OMe-ONP-OSu-NH2-OEt-AMC-NHMe-ol-OBzl-AFC-NHEt
03
Fatty Acidification
36 OPTIONSLipidation and acylation to enhance membrane affinity, half-life, and pharmacokinetic behavior.
ForMeOSuc5-Hexynoic acidF-Lau-MeOCOIbaHeptanedioic acidMyr-2-Br-Acpentenoic acidOct-F-Myr-2-Cl-AcpentinoylF-Oct-Pentadeconyl-2-I-AcHex-Dec-Pal-OH-Ac5-heptenoic acidSebacic acidCys (Pal)3-BromopropionylTrans-3-hexenoyl-F-Dec-Pam3C-But-Linoletic-Undecyl-Ste-Suc10,12-Pentacosadiynoic acidLau-Octanedioic acid
04
Methylation
11 OPTIONSBackbone and side-chain methylation to modulate receptor selectivity and enzymatic stability.
Lys (Me)Arg (Me)Tyr (Me)Tyr (Et)Lys (Me2)Arg (Me2) asymmetricalThr (Me)D-Tyr (Et)Lys (Me3)Arg (Me2) symmetricalSer (Me)
05
Phosphorylation
10 OPTIONSSingle- and multi-site phosphorylation for kinase substrates and signaling studies.
pSerD-pSerDi-sites in sequence4-sites in sequencepTyrD-pTyrTri-sites in sequence5-sites in sequencepThrD-pThr
06
Branch Peptide
14 OPTIONSMAP and branched architectures for multivalent antigen presentation and enhanced activity.
Symmetric 2 BranchesSymmetric 4 BranchesSymmetric 8 BranchesLys symmetric 2 BranchesLys symmetric 4 BranchesLys symmetric 8 BranchesOrn symmetric 2 BranchesOrn symmetric 4 BranchesOrn symmetric 8 BranchesGlu 2 Branches (Pure)Glycerol 3 Branches esterThr (Peptide2)Ser (Peptide2)Lys (Peptide2)
07
Cyclic Peptide
10 OPTIONSDisulfide, amide, and selenium-based cyclization for conformationally constrained peptides.
Mono Disulfide bridgeDouble Disulfide bridgeTriple Disulfide bridgeRandom Triple Disulfide bridgeAmide Cyclic (side chain) by LysAmide Cyclic (side chain) by OrnOxidation between Se-CysAmide Cyclic (end)Same Sequence Inter-Disulfide bridge by Cys oxidationDifferent Sequence Inter-Disulfide bridge by Cys oxidation
08
Fluorescence / Dye Labeling
50 OPTIONSFluorophores, biotin, and affinity tags for imaging, binding, and detection assays.
Biotin-FITC-Dansyl-Lys (Dnp)DeThioBiotin-ED-FITC-EDDansylD-Lys (Dnp)-EDBiotin-Lys (FITC)--Lys (Dansyl)-Dab (Dnp)Glu (Biotin-PEG2)-Lys (FITC)-Lys (Dansyl)Dap (Dnp)-Lys (Biotin)-Lys (Ahx-FITC)Dansli-e-Lys-EDDnp-Lys (Biotin)FITC-e-LysDansyl-Ahx--Lys (LC-Biotin)-FITC-Ahx-5-FAM--Lys (LC-Biotin)5-TAMRA-5,6-FAMBiotin-e-Lys5 (6)-TAMTA-6'FAMLys (S-S-Biotin)-EDYAMRA-ED-5-FAMBiotin-Ahx--Lys (TAMRA)--Lys (5-FAM)-Orn (Bio)-Lys (5-TAMRA)Lys (5,6-FAM)MCA-5-TAMRA-e-Lys-Lys (5-FAM)-Lys (MCA)-5-TAMRA-Acp5-FAM-E-Lys-Lys (MCA)5-FAM-Ahx-Lys (MCA)-
09
BSA, KLH, OVA Coupling
9 OPTIONSCarrier-protein conjugation for antibody production and immunoassay development.
BSA-Peptide N terminusKLH-Peptide N terminusOVA-Peptide N terminusBSA-Peptide C terminusKLH-Peptide C terminusOVA-Peptide C terminusBSA-Peptide via CysKLH-Peptide via CysOVA-Peptide via Cys
10
Phe & Tyr Derivative
46 OPTIONSHalogenated, nitrated, and methylated aromatic residues for SAR exploration.
D-2-Cl-PheD-4-F-PheL-2-Me-PheL-3-I-TyrL-2-Cl-PheL-4-F-PheD-4-Me-PheD-3,5-DiI-TyrD-3-Cl-PheD-4-NO2-PheL-4-Me-PheL-3,5-DiI-TyrL-3-Cl-PheL-4-NO2-PheD-4-NH2-PheD-3-NO2-TyrD-4-Cl-PheD-4-I-PheL-4-NH2-PheL-3-NO2-TyrL-4-Cl-PheL-4-I-PheD-3-Cl-TyrD-3,5-DiNO2-TyrD-3,4-DiCl-PheD-3-CN-PheL-3-Cl-TyrL-3,5-DiNO2-TyrL-3,4-DiCl-PheL-3-CN-PheD-3,5-DiCl-TyrL-3-F-TyrD-4-Br-PheD-4-CN-PheL-3,5-DiCl-TyrL-4-NO2-PhgL-4-Br-PheL-4-CN-PheD-3,5-DiBr-TyrD-4-NO2-PhgD-3-F-PheD-2-Me-PheL-3,5-DiBr-TyrL-3,5-DiF-PheL-3-F-PheD-3-I-Tyr
11
Linker
11 OPTIONSFlexible spacers and PEG linkers optimizing conjugate geometry and solubility.
GlyAvaAEAGABABeta-AlaAhxAdoMini-PEGMini-PEG2Mini-PEG3PEG4
12
Resin
4 OPTIONSPeptides supplied still attached to your resin of choice for on-resin downstream chemistry.
peptide on Wang Resinpeptide on 2-CTC Resinpeptide on Rink Amide AM Resinpeptide on Rink Amide MBHA Resin
13
D-Amino Acid
18 OPTIONSFull D-enantiomer substitutions for protease-resistant and mirror-image peptides.
D-AlaD-LysD-GluD-TyrD-ArgD-MetD-GlnD-ThrD-AspD-ProD-HisD-TrpD-AsnD-PheD-LeuD-ValD-CysD-Ser
14
Homotype Amino Acids
28 OPTIONSHomo- and beta-homo analogues extending side-chain reach and conformational space.
HarHomoCitbeta-HomoMetbeta-HomoSerD-HarD-HomoCitbeta-HomoProbeta-HomoThrHcyHomoLeubeta-HomoValbeta-HomoTrpHPhHomoProbeta-HomoAspbeta-HomoTyrD-HPhD-HomoProbeta-HomoAsnAzidohomoalanineHsebeta-HomoIlebeta-HomoGlubeta-HomoAlaD-Hsebeta-HomoLeubeta-HomoGlnbeta-HomoPhe
15
Special Amino Acids
123 OPTIONSAn extensive palette of unnatural, protected, and functionalized residues for advanced designs.
beta-Asp3-ThiD-ChgCys (pMeBzl)D-beta-AspAibAc6cCys (pMeOBzl)gamma-GluAbuDabOicD-gamma-GluD-AbuDapTicCys (Cam)HypPraD-TicD-Cys (Cam)PhgD-PraCys (Bzl)Cys (Acm)D-PhgAllo-ThrEpsilon-LysCys (tBu)NvaD-Allo-ThrD-Epsilon-LysCys (StBu)D-NvaGly (allyl)5-ASAMet (O)NleD-Gly (allyl)BpaD-Met (O)D-NleCys (Pyrene-maleimide)PipCys (SNO)CitD-1-NalNipMet (O)2D-CitL-1-Nal2-AzeD-Met (O)2OrnD-2-Nal3-AzeLys (Ac)D-OrnL-2-Nal[Psi (CH2NH)]Ac-LysPenD-2-Pal[CS-NH]Lys (Dde)D-PenL-2-PalSe-MetTleCpgD-3-PalSe-CysSer (Octanoic acid)ChaL-3-palDOPASer (Lipoic acid)D-ChaD-4-PalisoGlnD-Ser (Octanoic acid)ChgL-4-PalD-isoGlnArg (Boc2)Asp-OMeD-Glu (OtBu)Lys (Z)Arg (NO2)Asp-OtBuGln (Trt)Ser (Bzl)Arg (Z2)Asn (Trt)His (Boc)Ser (Trt)Arg (pbf)Cys (MMt)His (Trt)Ser (tBu)D-Arg (pdf)Cys (Trt)Tyr (propargyl)Tyr (tBu)Asp (Oall)D-Cys (Trt)Lys (Boc)Asp (OBn)Glu (Oall)Lys (DMT)D-Tyr (tBu)Asp (OBzl)Glu (OBzl)Lys (Fomc)Thr (tBu)Asp (OMe)Glu (OMe)Lys (Mtt)Trp (Boc)Asp (OtBu)Glu (OtBu)Lys (Trt)Trp (Farnesyl)
i
Notice
1. The above information is for reference only, and your customized peptide modification requirements will be submitted to the laboratory for evaluation.
2. If you have any peptide modification requirements that are not listed in the table, you can contact us directly for consultation.
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Modification Capabilities
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Catalogued Options
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