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| Description | Angiotensin Ⅱ is the core effector molecule of the renin-angiotensin-aldosterone system. By specifically binding to AT₁ receptors on vascular smooth muscle cells, it potently constricts systemic resistance vessels, increases peripheral resistance and raises arterial blood pressure. It also acts on the zona glomerulosa of the adrenal cortex to promote aldosterone synthesis and secretion, enhancing renal water and sodium reabsorption and expanding blood volume to jointly maintain blood pressure and water-electrolyte homeostasis. It is also involved in multiple pathophysiological processes including vascular remodeling, myocardial hypertrophy, renal fibrosis and inflammatory responses. The human sequence is directly applicable to human-related cell and animal studies. It is a classic tool peptide for hypertension mechanism research, renin-angiotensin system functional verification and cardiovascular drug development, and is widely used for hypertension model construction and antihypertensive drug screening. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₅₀H₇₁N₁₃O₁₂ |
| Molecular weight (Da) | 1046.2 |
| Structure type | Linear octapeptide, endogenous bioactive peptide, free peptide |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Angiotensin Ⅱ human | Angiotensin Ⅱ human | Angiotensin receptor agonist, vasoconstriction & hypertension, aldosterone secretion, hypertension modeling | Human linear octapeptide, sequence identical to endogenous form; agonizes both AT₁ and AT₂ receptors | C₅₀H₇₁N₁₃O₁₂ | 1045.53 | 1046.2 | Free peptide | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-ANG001 | White powder | Store at -20°C, sealed and dry. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack recommended. | Stable for 7 days at 4°C. Highly soluble in water, dilute acetic acid and PBS physiological buffers. Better stability under acidic conditions; also stable in neutral solution. | Stable for 2 years at -20°C, dry condition. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ANG001 | Human octapeptide core effector activates AT receptors to raise blood pressure and promote aldosterone secretion for hypertension modeling | Angiotensin Ⅱ is the core effector molecule of the renin-angiotensin-aldosterone system. By specifically binding to AT₁ receptors on vascular smooth muscle cells, it potently constricts systemic resistance vessels, increases peripheral resistance and raises arterial blood pressure. It also acts on the zona glomerulosa of the adrenal cortex to promote aldosterone synthesis and secretion, enhancing renal water and sodium reabsorption and expanding blood volume to jointly maintain blood pressure and water-electrolyte homeostasis. It is also involved in pathophysiological processes including vascular remodeling, myocardial hypertrophy, renal fibrosis and inflammatory responses. The human sequence is directly applicable to human-related cell and animal studies, and is a classic modeling reagent for hypertension research. | Hypertension mechanism research, renin-angiotensin system study, cardiovascular disease research, aldosterone secretion study, vascular remodeling study | Angiotensin type 1 receptor (AT₁), angiotensin type 2 receptor (AT₂); Vasoconstriction and water-electrolyte balance regulatory pathway |
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