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| Description | This designed biotinylated peptide incorporates Abu to replace oxidation-prone sites (improving metabolic stability) and uses Cys-Ser-related cyclization to constrain conformation, with C-terminal amidation. The biotin tag enables streptavidin immobilization/detection for target-binding and affinity studies of conformationally constrained peptide ligands. |
| CAS No. | 396679-25-7 |
| Structure type | Linear/cyclic peptide with Abu and cyclization (N-biotinylated, C-amide) |
| Solubility | Readily soluble in water/PBS; minor cosolvent for hydrophobic sequence |
| Storage | Powder, −20°C, dry, light-protected |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| K(biotinyl)-KEDVV-Abu-CS-Abu-SYKK-NH2 (Lys(biotinyl)-Lys-Glu-Asp-Val-Val-Abu-Cys-Ser-Abu-Ser-Tyr-Lys-Lys amide) | Biotin-KEDVV-Abu-CS-Abu-SYKK-NH2; biotinylated KEDVV-Abu-CS-Abu-SYKK amide; CAS 396679-25-7; MCE HY-P4026 / AbMole M51314 | biotin-labeled peptide, C-terminal amidated, Abu (alpha-aminobutyric acid) non-natural residue, free Cys (thiol), protease-stabilized, streptavidin capture probe | Linear 14-mer with the epsilon side-chain amine of the N-terminal Lys conjugated via an amide bond to biotin; sequence Lys(biotinyl)-Lys-Glu-Asp-Val-Val-Abu-Cys-Ser-Abu-Ser-Tyr-Lys-Lys-NH2; contains 2 non-natural Abu (alpha-aminobutyric acid, C-alpha side chain -CH2CH3, one extra CH2 vs Ala, net +C4H7NO/residue); 1 free Cys (single Cys, no intramolecular disulfide, free thiol oxidation-prone); C-terminal amidation (-CONH2, removes C-terminal negative charge); biotin net addition C10H14N2O2S; net charge near positive (multiple Lys side-chain positives vs Glu/Asp side-chain negatives); Abu substitution confers protease/oxidation resistance | C79H133N21O23S2 | 1807.93 | 1809.18 | Free base/amide (C-terminal -NH2); TFA/acetate forms available on request; CAS 396679-25-7 | 14 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BKEDVV-01 | White to off-white powder (biotin is colorless) | Store at -20°C, sealed, desiccated, ~3 years (per supplier); contains free Cys thiol-store under antioxidant/inert gas (nitrogen/argon), avoid reducing agents; aliquot and avoid repeated freeze-thaw. | 2-8°C for up to ~2 years; working aliquots -80°C ~6 months, -20°C ~1 month (sealed, dry); avoid room-temperature exposure. | Dissolve in sterile water or neutral buffer (pH 7.4 PBS); a small amount of DMSO may be used as co-solvent. Contains free Cys: in solution it readily oxidizes in air to dimers/oligomers-avoid air exposure and oxidizing buffers; do not use strong reducing agents (DTT/TCEP) unless intentionally reducing the free thiol. The biotin tag is for streptavidin capture/immobilization; the free Cys thiol can be used for thiol-specific conjugation (e.g., maleimide labeling). Prepare fresh. | solid stable for ~3 years at -20°C, sealed, dry, under inert gas; Cys is oxidation-prone-keep dry and oxygen-free; biotin itself is stable. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BKEDVV-01 | Biotinylated, C-terminally amidated, Abu (alpha-aminobutyric acid)-substituted research peptide containing a free Cys (14-mer, CAS 396679-25-7); biotin for streptavidin capture, free Cys as a thiol-conjugation handle, Abu substitution for protease stability. | K(biotinyl)-KEDVV-Abu-CS-Abu-SYKK-NH2 is a synthetic research peptide with multiple engineering modifications: backbone Lys(biotinyl)-Lys-Glu-Asp-Val-Val-Abu-Cys-Ser-Abu-Ser-Tyr-Lys-Lys-NH2 (14 residues, CAS 396679-25-7). It embodies common peptide-tool design strategies: (1) N-terminal Lys side-chain biotinylation-provides an ultra-high-affinity streptavidin capture tag (Kd≈10^-14 M) for immobilizing the peptide on solid supports (ELISA plates, magnetic beads, affinity columns, chips) or detection/tracing via fluorescent/enzyme-conjugated streptavidin, a standard modification for pulldown, receptor/ligand binding, and peptide-library display; (2) C-terminal amidation (-NH2)-removes the C-terminal carboxyl negative charge, mimics a neutral amide terminus in vivo, improves stability and membrane permeability, and eliminates the C-terminal charge contribution; (3) two Abu (alpha-aminobutyric acid) non-natural substitutions-Abu has an ethyl side chain (-CH2CH3), spatially resembling methionine/leucine but lacking an oxidizable thioether, preserving hydrophobicity while resisting proteases (especially Met/Leu-specific proteases) and oxidation, markedly extending half-life in serum/tissue; (4) a single free Cys-provides a unique free thiol (-SH) as a site-specific conjugation handle for maleimide/iodoacetamide thiol chemistry to attach fluorophores, drugs, polymers, or carrier proteins for site-specific labeling. Overall, the peptide suits research scenarios requiring biotin capture, site-specific thiol conjugation, and protease-stabilized peptide tools/probes (e.g., receptor-binding pulldown, peptide-protein interactions, affinity purification, site-specific labeling). **Basis and notes**: mainstream suppliers (MCE HY-P4026, AbMole M51314, Pharmaffiliates PA PEP003717) sell it as a biotinylated synthetic peptide, publishing formula C79H133N21O23S2 and MW≈1809.16-1809.18 Da, without a specific natural ligand/receptor activity; its biological use is driven by these engineered modifications. Contains free Cys-protect solutions from oxidation, avoid strong reducing agents, use low-binding tubes, prepare fresh, and keep under inert gas. | biotinylated synthetic peptide/probe, streptavidin capture/immobilization, free Cys thiol site-specific conjugation, Abu non-natural residue anti-protease/antioxidant, C-terminally amidated peptide, peptide-protein interaction pulldown, affinity purification/peptide-library display, site-specific fluorophore/drug labeling | streptavidin (biotin capture, Kd≈10^-14 M); free Cys thiol (maleimide/iodoacetamide site-specific conjugation); no specific natural target annotated by suppliers |
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