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| Description | Thiostrepton is a classic thiopeptide antibiotic. By specifically binding to the 23S rRNA of the 50S ribosomal subunit in bacteria, it inhibits the translocation reaction of aminoacyl-tRNA, blocks bacterial protein synthesis, and exerts potent antibacterial activity against Gram-positive bacteria. In eukaryotic cells, it inhibits the chymotrypsin-like activity of the proteasome and downregulates the expression of transcription factor FOXM1, exerting anti-proliferative and pro-apoptotic effects on tumor cells. It is widely used in bacterial protein synthesis mechanism research, proteasome function study, tumor targeted therapy research and antibacterial drug development, and is a classic tool reagent for microbiology and oncology research. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₇₂H₈₅N₁₉O₁₈S₅ |
| Molecular weight (Da) | 1664.9 |
| Structure type | Polycyclic thiopeptide with multiple thiazole rings, free peptide |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Thiostrepton | Thiostrepton | Thiopeptide antibiotic, ribosome inhibitor, antitumor, FoxM1 inhibition | Natural polycyclic thiopeptide with multiple thiazole/thiazoline rings and dehydroamino acids; targets bacterial 23S rRNA to inhibit protein synthesis | C₇₂H₈₅N₁₉O₁₈S₅ | 1663.54 | 1664.9 | Free peptide | Polycyclic thiopeptide |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-THI001 | Yellow to tan crystalline powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack recommended. | Stable for 7 days at 4°C. Freely soluble in DMSO, DMF and methanol. Very low water solubility; requires co-solvent. Unstable under strong acid and alkali. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-THI001 | Polycyclic thiopeptide antibiotic inhibits ribosome and proteasome with antibacterial and antitumor activities | Thiostrepton is a classic thiopeptide antibiotic. By specifically binding to the 23S rRNA of the 50S ribosomal subunit in bacteria, it inhibits aminoacyl-tRNA translocation, blocks bacterial protein synthesis, and exerts potent antibacterial activity against Gram-positive bacteria. In eukaryotic cells, it inhibits the chymotrypsin-like activity of the proteasome and downregulates the expression of transcription factor FOXM1, arresting tumor cell cycle and inducing apoptosis. It is widely used in bacterial protein synthesis mechanism research, proteasome function study, tumor targeted therapy research and antibacterial drug development. | Bacterial protein synthesis research, proteasome function study, tumor targeted therapy research, antibacterial drug development, FoxM1 pathway study | Bacterial 23S rRNA, eukaryotic proteasome, FOXM1; Protein synthesis inhibition and tumor proliferation regulatory pathway |
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