Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of trofinetide in China, also supports custom service. Welcome to wholesale bulk high quality trofinetide from our factory. Contact us for more details.
| Description | Trofinetide is a centrally active synthetic tripeptide derivative that mimics the function of GPE, the N-terminal active fragment of endogenous IGF-1. It can cross the blood-brain barrier into the central nervous system, activate IGF-1 related signaling pathways in neurons and glial cells, promote neuronal survival, synaptogenesis and myelination, while inhibiting excessive microglial activation and alleviating neuroinflammatory responses. It exhibits definite neuroprotective, functional improvement and anti-inflammatory effects in models of Rett syndrome, autism spectrum disorder, cerebral ischemic injury and neurodegenerative diseases. It is an important tool peptide for neurodevelopment mechanism research, brain injury repair research and neurological disease drug development. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₁₁H₁₈N₂O₅ |
| Molecular weight (Da) | 258.27 |
| Structure type | Modified tripeptide, CNS permeability optimized, free form / acetate |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Trofinetide | Trofinetide | IGF-1 pathway agonist, neuroprotection, blood-brain barrier penetration, neurodevelopment & repair | Synthetic tripeptide derivative, mimics the structure of IGF-1 N-terminal GPE active fragment, crosses the blood-brain barrier, activates IGF-related pathways in central neurons and glial cells | C₁₁H₁₈N₂O₅ | 258.12 | 258.27 | Free form / acetate | 3 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-TRO001 | White crystalline powder | Store at -20°C, sealed and dry; also stable for long-term storage at room temperature. | Stable for 6 months at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 30 days at 4°C. Highly soluble in water and normal saline. Excellent thermal stability in aqueous solution; resistant to routine autoclaving. | Stable for 3 years at -20°C and 2 years at room temperature, dry condition. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-TRO001 | Blood-brain barrier permeable tripeptide activates central IGF pathway for neuroprotection | Trofinetide is a centrally active synthetic tripeptide derivative that mimics the function of GPE, the N-terminal active fragment of endogenous IGF-1, and freely crosses the blood-brain barrier into the central nervous system. By activating IGF-1 related signaling pathways in neurons and glial cells, it promotes neuronal survival, synaptogenesis and myelination, while inhibiting excessive microglial activation and alleviating neuroinflammatory responses, improving neurological function damage. It exhibits definite neuroprotective, functional improvement and anti-inflammatory effects in models of Rett syndrome, autism spectrum disorder, cerebral ischemic injury and neurodegenerative diseases. It is an important tool peptide for neurodevelopment mechanism research, brain injury repair research and neurological disease drug development. | Neurodevelopmental disorder research, cerebral ischemic injury study, neurodegenerative disease research, blood-brain barrier drug study, neuroinflammation research | Central IGF-1 signaling pathway; Neuronal survival and neuroinflammation regulatory pathway |
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