Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of cas 131602-53-4 β-amyloid (25-35) in China, also supports custom service. Welcome to wholesale bulk high quality cas 131602-53-4 β-amyloid (25-35) from our factory. Contact us for more details.
| Description | GSNKGAIIGLM (residues 25–35), one of the shortest functional fragments retaining aggregation and neurotoxicity (oxidative stress, neuronal injury); a common short in-vitro toxicity model. |
Product Basic Information Table
| Standard English Name | Abbreviations/Aliases | Functional Tags | Structural Core | Molecular Formula | Exact MW (Da) | Average MW (Da) | Salt Form | Length (aa) |
| β-Amyloid (25-35), CAS:131602-53-4 | Aβ(25-35); Amyloid-beta 25-35; Neurotoxic core fragment | Alzheimer disease,Aβ neurotoxic core,aggregation,neurotoxicity,mitochondrial dysfunction,oxidative stress,calcium overload,membrane permeabilization,short tool peptide | GSNKGAIIGLM | C45H81N13O14S1 | 1059.57 | 1060.28 | Free acid | 11 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Stability |
| PEP-AB2535-01 | White to off-white /solid powder; relatively lipophilic. | -20 °C, dry, light-protected, sealed. | 2–8 °C short-term; dissolve in DMSO or water, aliquot and store at -20 °C. | Slowly aggregates in water while retaining neurotoxicity; relatively lipophilic, dissolve in DMSO then dilute into aqueous buffer; prepare fresh as aggregation progresses over time. | Solid powder stable ≥2 years at -20 °C dry & light-protected. |
Functional Description
| Product Code | Short Summary (listing) | Detailed Biological Function | Research Areas | Targets/Receptors |
| PEP-AB2535-01 | 11-aa neurotoxic core of Aβ; retains aggregation and neurotoxicity, a widely used cost-effective tool peptide for AD mechanism and drug screening. | Aβ(25-35) (GSNKGAIIGLM) is the C-terminal hydrophobic core fragment of human Aβ that retains major neurotoxicity; it can be generated by proteolytic cleavage in brain. Despite only 11 residues, it recapitulates most key toxicities of full-length Aβ: it aggregates into β-sheet oligomers/fibrils in aqueous phase; inserts into neuronal membranes forming ion channels/pores causing Ca²⁺ overload; triggers mitochondrial membrane depolarization, ROS/free-radical generation and lipid peroxidation; activates caspase-3/9 apoptotic pathways; promotes microglial activation and IL-1β/TNF-α release; and induces tau hyperphosphorylation. Inexpensive, stable and directly bioactive, it is widely used for cell/animal-level AD drug primary screening and toxicity-mechanism studies. | Alzheimer disease,Aβ toxicity mechanism,mitochondrial damage,oxidative stress,calcium overload,primary drug screening,neuronal apoptosis | Neuronal membrane (pore/channel); mitochondria; NMDA receptor; microglial NLRP3; tau kinases (GSK-3β, CDK5) |
Hot Tags: cas 131602-53-4 β-amyloid (25-35), China cas 131602-53-4 β-amyloid (25-35) manufacturers, suppliers, factory, Amyloid 1 28 , 186359-65-9, 190436-05-6, 659739-33-0, CAS 152286 31 2, CAS 190436 05 6
