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| Description | Spans Lys28 (salt-bridge partner) through GSNKGAI toward the hydrophobic C-terminus; used to study the transition segment linking the central region to the C-terminal core in fibril formation. |
Product Basic Information Table
| Standard English Name | Abbreviations/Aliases | Functional Tags | Structural Core | Molecular Formula | Exact MW (Da) | Average MW (Da) | Salt Form | Length (aa) |
| β-Amyloid (28-35), human | Aβ28-35; Amyloid-β 28-35; KGAIIGLM; CAS 182945-56-8 | Aβ C-terminal short fragment, neurotoxicity model, membrane interaction, Met oxidation-prone, aggregation study | 8-mer, sequence KGAIIGLM; the Aβ C-terminal 28-35 fragment containing Met35; free N-terminus and C-terminus; short and weakly aggregating; C-terminal hydrophobic IGLM and Met35 participate in membrane insertion and neurotoxicity; Met35 readily oxidizes to MetO35 with loss of toxicity, requiring oxygen-free storage. | C36H67N9O9S | 801.48 | 802.05 | TFA salt / powder | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Stability |
| PEP-AB2835-01 | White to off-white powder | -20°C, sealed, dry, light-protected, aliquots; ~2 years. Met-containing peptides require inert-gas (Ar/N2) headspace to prevent oxidation | 2-8°C for ~1 week; working aliquots stored at -20°C, avoid repeated freeze-thaw | Good aqueous solubility; reconstitute directly in sterile water or buffer. Because of the oxidation-prone Met35, prepare working solutions fresh, keep under Ar/N2 headspace and use promptly to avoid oxidation to methionine sulfoxide (MetO35), which abolishes neurotoxicity. | solid stable ~2 years at -20°C, dry and sealed. Because it contains Met35, the vial must be kept under inert-gas (Ar/N2) headspace, protected from light, both before and after opening; equilibrate to RT in a desiccator before weighing to prevent moisture uptake and oxidation. |
Functional Description
| Product Code | Short Summary (listing) | Detailed Biological Function | Research Areas | Targets/Receptors |
| PEP-AB2835-01 | Human Aβ(28-35) octapeptide KGAIIGLM (CAS 182945-56-8), an Aβ C-terminal short fragment containing the key residue Met35. A classic short-peptide model for Aβ C-terminal neurotoxicity, membrane interaction and redox studies; weakly aggregating 8-mer with oxidation-prone Met requiring inert-gas storage. | Aβ(28-35), KGAIIGLM, is one of the most neurotoxic short functional fragments at the C-terminus of Aβ. Despite only 8 residues, it retains the C-terminal hydrophobic core and the critical Met35 residue. Aβ28-35 is reported to insert into membranes, perturb calcium homeostasis, induce reactive oxygen species (ROS) and cause mitochondrial damage, making it a widely used short-peptide tool for in vitro neurotoxicity models. Its toxicity strongly depends on the reduced state of Met35: oxidation of Met35 to methionine sulfoxide (MetO35) markedly reduces membrane disruption and neurotoxicity, and the redox state of Met35 is therefore regarded as a key switch regulating Aβ toxicity. This peptide aggregates less than full-length Aβ and has good aqueous solubility, suitable for: membrane interaction / ion-channel formation, oxidative stress and mitochondrial toxicity, calcium-signaling dysregulation, and structure-activity studies of Met oxidation. Because Met35 is highly oxidation-prone, the product must be stored under inert gas, protected from light, and working solutions should be prepared fresh. | Alzheimer's disease (AD) neurotoxicity, Aβ C-terminal fragment, membrane interaction / ion channels, oxidative stress / ROS, Met redox structure-activity, short-peptide toxicity model | Cell membrane / lipid bilayer; Met35 redox; calcium-channel / mitochondrial ROS pathways |
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