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| Description | XT-1 (CAS: 398143-78-7) is a 27-residue cationic antimicrobial peptide isolated from the skin secretion of the tropical clawed frog Xenopus tropicalis, sequence GFLGPLLKLAAKGVAKVIPHLIPSRQQ. Molecular formula C134H227N37O31, MW 2852.47 Da. XT-1 shows MICs of 5, 6, and 50 uM against Staphylococcus aureus, Escherichia coli, and Candida albicans, respectively, demonstrating broad-spectrum antibacterial and antifungal activity. XT-1 belongs to the X. tropicalis XT peptide family together with XT-2 and XT-3, representing the skin host defense peptide repertoire of X. tropicalis that evolved in parallel with the magainin, xenopsin, and PGQ peptides of X. laevis. XT-1 adopts an amphipathic conformation and acts by membrane disruption. XT-1 is a tool for studying tropical clawed frog innate immunity and species diversification of Xenopus AMPs. |
| Structure type | Linear 27-mer (X. tropicalis skin XT family amphipathic cationic peptide) |
| Solubility | Readily soluble in water, dilute acetic acid |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| XT‑1 | Scorpion venom peptide XT‑1; Mesobuthus martensii peptide XT‑1 | Antimicrobial peptide, broad‑spectrum antibacterial, anticancer, scorpion venom peptide, antiparasitic | Cationic active peptide from Mesobuthus martensii venom, highly homologous to XT‑2, with an amphipathic structure; potently inhibits Gram‑positive bacteria and tumor cell proliferation, with combined antiparasitic activity | C₁₆₉H₂₇₃N₄₅O₄₂S₃ | 3680.01 | ~3682.5 | Acetate | 33 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-XT01 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in dilute acetic acid and acidic buffers. Cationic amphipathic structure with good activity at physiological salt concentrations. Sensitive to proteases with short in vivo half-life. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-XT01 | Scorpion venom peptide XT-1 with antibacterial and antiparasitic activity | XT-1 is a homologous cationic active peptide from Mesobuthus martensii venom, highly homologous to XT-2 in sequence. It exerts potent inhibitory activity against Gram-positive pathogens, while inhibiting parasite growth and killing tumor cells. The mechanism is dominated by membrane disruption combined with intracellular targeting, serving as a model for studying structure-activity relationships and antiparasitic effects of scorpion-derived AMPs. | Scorpion venom peptide research, antimicrobial peptides, antiparasitics, anticancer, structure-activity relationship | Microbial membrane permeabilization; parasite membrane damage; tumor proliferation inhibition |
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