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| Description | Malformin C is a natural bicyclic pentapeptide isolated from fungi (such as Aspergillus niger), with CAS number 59926-78-2, structure cyclo(D-Cys-D-Cys-L-Val-D-Leu-L-Leu), in which the two cysteine residues (Cys1-Cys2) are bridged by a disulfide bond, forming a bicyclic (two-ring) structure, with a theoretical molecular weight of 529.72 Da and molecular formula C₂₃H₃₉N₅O₅S₂. Malformin C belongs to the malformin family of natural products, a class of cyclic disulfide-containing pentapeptides produced by fungi. The malformin family compounds were originally named for causing plant malformation, and are secondary metabolites produced by phytopathogenic fungi. The unique bicyclic structure of Malformin C (formed by cyclization of the peptide backbone and disulfide bridging) provides high conformational stability and metabolic stability. Malformin C possesses antibacterial activity, particularly inhibitory activity against bacteria of the genus Bacillus. In addition, malformin family compounds have been reported to possess phytotoxicity (causing plant growth malformation) and other biological activities. Its antibacterial mechanism may involve interference with bacterial cellular metabolism or cell membrane integrity. As a natural fungus-derived bicyclic pentapeptide, Malformin C is widely used in natural product chemistry research, cyclic peptide drug development, antibacterial activity screening, structure-activity relationship research of disulfide-containing cyclic peptides, and fungal secondary metabolite research. |
| Molecular formula | C₂₃H₃₉N₅O₅S₂ |
| Molecular weight (Da) | 529.72 |
| Structure type | Cyclic pentapeptide (fungus-derived bicyclic peptide, Cys-Cys disulfide bridge, cyclo(D-Cys-D-Cys-L-Val-D-Leu-L-Leu), anti-Bacillus) |
| Solubility | Freely soluble in DMSO, methanol; slightly soluble in water |
| Storage | -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Combi‑2 | Combinatorial antimicrobial peptide 2 | Antimicrobial peptide, broad‑spectrum antibacterial, antibiofilm, anti‑inflammatory, anti‑infection | Artificially designed dual‑domain fusion antimicrobial peptide composed of a cationic helical domain and a proline‑rich domain; combines membrane penetration and intracellular target inhibition, with rapid bactericidal activity against both Gram‑positive and Gram‑negative bacteria, biofilm inhibition and prominent anti‑inflammatory activity | C₁₁₂H₁₉₇N₃₅O₁₈ | 2458.51 | ~2460.1 | Acetate | 24 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-COMBI2 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in dilute acetic acid and acidic buffers. Dual-domain design ensures broad pH stability and protease resistance; optimal antibacterial and anti-inflammatory activity at physiological pH. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-COMBI2 | Dual-domain Combi-2 fusion peptide with broad antibacterial, anti-inflammatory and antibiofilm activity | Combi-2 is an artificially designed bifunctional fusion antimicrobial peptide. The N-terminal cationic α-helical domain mediates rapid bacterial membrane penetration, while the C-terminal proline-rich domain binds intracellular targets to inhibit protein function. It combines rapid bactericidal and long-acting bacteriostatic effects, with high activity against both Gram-positive and Gram-negative bacteria, biofilm inhibition and anti-inflammatory activity. | Broad-spectrum anti-infective drugs, biofilm-associated infections, anti-inflammatory peptide development, fusion peptide design, immunomodulation | Bacterial membrane penetration; intracellular protein function inhibition; inflammatory cytokine release pathway |
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