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| Description | Cyclopetide 2 (CAS: 748142-26-9, also known as Compound 2) is a cyclic tripeptide isolated from a Ruegeria sp. bacterium associated with the marine sponge Suberites domuncula, with the sequence Cyclo(Gly-Pro-Glu) (cyclized GPE). Molecular formula C₁₂H₁₇N₃O₅, molecular weight 283.28 Da. Cyclopetide 2 exhibits moderate antibacterial activity against Bacillus subtilis, with a minimum inhibitory concentration (MIC) of 50 μg/mL. As a cyclic peptide containing only 3 amino acid residues, Cyclopetide 2 demonstrates that a minimal cyclic scaffold can still possess biological activity, and its cyclic structure confers resistance to proteolytic degradation. Cyclopetide 2 is an important tool for studying marine symbiotic microbial natural products, antimicrobial activity of miniature cyclic peptides, and developing novel anti-Gram-positive bacterial compounds. |
| Structure type | Cyclo(GPE) tripeptide (cyclic, protease-resistant) |
| Solubility | Readily soluble in DMSO, methanol, water |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Cyclopetide 2 | Cyclic peptide 2; amide-cyclized antimicrobial peptide | Cyclic peptide, antimicrobial peptide, anti-resistant bacteria, protease-resistant, membrane-active peptide | Artificially synthesized head-to-tail amide-cyclized cationic peptide; rigid cyclic conformation significantly improves protease resistance and in vivo stability; binds and disrupts bacterial cell membranes | C₅₆H₉₁N₁₅O₉ | 1153.71 | ~1154.6 | Free peptide | 9 (cyclic) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CYCP2 | White to off-white crystalline powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Moderate water solubility; soluble in DMSO, methanol and dilute acetic acid. Cyclic conformation is protease-resistant and stable over a broad pH range. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CYCP2 | Cyclopetide 2 with high stability against drug-resistant bacteria | Cyclopetide 2 is an artificially synthesized head-to-tail amide-cyclized cationic antimicrobial peptide. The rigid cyclic conformation confers complete resistance to linear proteases and significantly better in vivo stability than linear peptides. It binds and disrupts bacterial cell membranes, with good bactericidal activity against MDR Gram-positive bacteria, serving as a lead for cyclic peptide antibiotic development. | Cyclic peptide antibiotics, resistant bacterial infections, protease-resistant peptides, AMP development, macrocyclic peptide drugs | Bacterial membrane integrity; cyclic conformation protease resistance; intracellular stability |
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