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| Description | GMPRGA (CAS: 2059978-58-2) is a 6-residue synthetic peptide, sequence Gly-Met-Pro-Arg-Gly-Ala, derived from the Bacillus phage Spbeta genome. Free-base formula C23H41N9O7S, MW 587.69 Da. GMPRGA is recognized and bound by the bacterial cytosolic spAimR repressor, inducing the phage Spbeta to enter the lysogenic cycle. GMPRGA is a tool for phage-host lysogeny-lysis decision switches, AimR-family repressor signal recognition, and microbial quorum-sensing research. The TFA salt improves aqueous solubility and storage stability. |
| Structure type | Linear 6-mer (phage Spbeta spAimR-recognition peptide, TFA salt) |
| Solubility | Readily soluble in water, dilute acetic acid |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| GMPRGA TFA | GMPRGA; Gly-Met-Pro-Arg-Gly-Ala; Spbeta phage AimR-inducing hexapeptide | hexapeptide, phage peptide, Spbeta, spAimR ligand, lysogeny-lysis switch, PPI probe, TFA salt, Met oxidation-sensitive | Linear 6-aa peptide, sequence Gly1-Met2-Pro3-Arg4-Gly5-Ala6 (Gly-Met-Pro-Arg-Gly-Ala), derived from the Spbeta-like phage AimP/AimX/AimR lysogeny regulatory system; free N-terminus +1, Arg side chain guanidinium +1, free C-terminus -1, no acidic residues, net charge ~+1; contains one Met (oxidation-sensitive), one Pro (conformational restriction), one Arg; 50% hydrophobic residues (Met, Pro, Ala); no Cys, Trp, His, no disulfide; short, flexible, hydrophilic, can diffuse into bacterial cytosol to bind spAimR | C23H41N9O7S | 587.29 | 587.70 | TFA (trifluoroacetate); formula and MW calculated for free peptide | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GMPRGA-01 | White powder | -20°C, desiccated, sealed, light-protected; contains Met which is prone to oxidation; flush with argon/nitrogen before sealing; avoid repeated freeze-thaw | 2-8°C, desiccated and light-protected, stable for 1-2 weeks | Short, net +1, largely hydrophilic peptide; readily soluble in water or aqueous buffers (PBS, Tris-HCl). The Met residue is easily oxidized to Met sulfoxide in solution, so prepare fresh and aliquot for -20°C storage; no DMSO needed; although there is no Trp, Met-containing peptides are best kept in brown tubes | Met is relatively stable; for long-term storage keep dry at -20°C under inert gas; short peptides are hygroscopic, seal tightly |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GMPRGA-01 | A Spbeta-phage-derived hexapeptide (Gly-Met-Pro-Arg-Gly-Ala) that binds spAimR in the bacterial cytosol to trigger the phage lysogeny-lysis decision; net charge +1, Met oxidation-sensitive. | GMPRGA is a six-residue signaling peptide derived from the lysogeny-lysis regulatory system of Bacillus subtilis Spbeta-like phages. In the Spbeta immune circuit, the phage proteins AimP/AimX sense host DNA damage (the SOS response) and proteolytically release a small peptide signal whose core active motif is GMPRGA. This hexapeptide diffuses in the bacterial cytosol and specifically binds the phage-encoded cI-like repressor spAimR (AimR immune protein), allosterically activating its cI-like repressor domain, shutting off phage lytic genes and maintaining lysogeny. Structural and functional work by Dou et al. (Nature Microbiology, 2018) showed that AimR is a phage-encoded CII/cI-type transcription factor with an N-terminal peptide-binding domain; GMPRGA embeds with high affinity into this pocket, inducing AimR dimerization and restoring repression of the lysis promoter. This revealed a new paradigm of peptide-signal-driven lysogeny decisions at the phage-host interface, analogous to bacterial quorum sensing but acting between viruses and their hosts. As the minimal active motif, GMPRGA is widely used as a tool to study the phage lysogeny-lysis switch, the AimR-AimP signaling axis, structural biology of peptide-repressor recognition, and lysogeny control in phage therapy. Its short length, good water solubility and ease of synthesis make it a convenient probe for phage immunology and synthetic-biology gene-switch applications. | phage biology, lysogeny-lysis decision, Spbeta/spAimR axis, peptide-protein interaction, structural biology probe, synthetic biology switch, phage therapy | Spbeta phage-encoded spAimR (AimR) immune repressor, cI-like transcription factor peptide-binding pocket |
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