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| Description | LA-Bac8c is an engineered N-terminal lipoic-acid (LA) conjugate of the natural bovine cathelicidin Bac8c (RIWVIWRR-NH2), linked via LA's carboxyl to the Bac8c N-terminus. Molecular formula C65H102N20O9S2, MW 1371.76 Da. Using lipoic acid as a hydrophobic fatty-acid ligand markedly enhances antibacterial potency: MICs against S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa are 1, 4, 8, 8, and 8 ug/mL respectively, lower than unmodified Bac8c. LA-Bac8c combines lipoic acid antioxidant activity with Bac8c membrane-disrupting action, serving as a tool for fatty-acid-conjugated short-AMP design and antimicrobial biomaterials. |
| Structure type | Lipidated 8-mer (lipoic acid-RIWVIWRR-NH2, C-amidated Trp/Arg-rich AMP) |
| Solubility | Readily soluble in DMSO, water |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| LA-Bac8c | Lipoic acid-modified Bac8c; LA-RIWVIWRR-NH2 | Antimicrobial peptide, Synthetic short peptide, Lipopeptide, Lipoic acid-modified, C-terminal amidated, Anti-Gram-positive, Anti-Gram-negative, Anti-MRSA, Membrane-active | 8-residue synthetic antimicrobial lipopeptide, an N-terminal lipoic acid (LA) conjugate of Bac8c derived from bovine neutrophil bactenecin; sequence LA-RIWVIWRR-NH2, where LA = 5-(1,3-dithiolan-4-yl)pentanoic acid (lipoic acid); C-terminally amidated; net charge +3 (3 Arg), Trp-containing hydrophobic residues; N-terminal lipidation enhances membrane affinity; contains a dithiolane (S-S) ring. | C65H102N20O9S2 | 1370.94 | 1371.78 | TFA salt (trifluoroacetate) | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-LABAC8C-01 | White powder | Store sealed, dry and protected from light at -20°C; light-sensitive due to Trp; avoid repeated freeze-thaw. | Ship/place short-term at 2-8°C; aliquotted working solution ~1 month at -20°C. | Moderate water solubility due to the N-terminal lipoic acid chain: first dissolve in a small volume of DMSO, then dilute with aqueous buffer to target concentration; protect from light due to Trp; do not keep solution at 4°C beyond 24 h. | Solid powder dry, light-protected, long-term >2 years at -20°C; stable for short-term shipping at room temperature. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-LABAC8C-01 | Lipoic acid (LA)-modified 8-residue synthetic antimicrobial lipopeptide derived from bactenecin analog Bac8c, C-terminally amidated, with broad-spectrum activity against Gram-positive/Gram-negative bacteria including MRSA; membrane-targeted bactericidal. | LA-Bac8c is a lipopeptide antimicrobial agent obtained by conjugating lipoic acid (LA) to the N-terminus of the synthetic 8-mer peptide Bac8c (sequence RIWVIWRR-NH2), itself a truncated optimized derivative of bovine neutrophil bactenecin/Bac2A. The appended lipoic acid greatly enhances membrane affinity and insertion, further improving antimicrobial potency over the parent Bac8c. LA-Bac8c potently inhibits S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, E. coli and P. aeruginosa, with MICs of 1, 4, 8, 8 and 8 μg/mL, respectively. Its bactericidal mechanism is predominantly membrane-targeted: the three Arg residues drive electrostatic attraction to negatively charged bacterial membrane components (lipoteichoic acid, LPS), while the lipoic acid lipid chain and Trp hydrophobic residues insert into the lipid bilayer, causing membrane depolarization, permeabilization and leakage of intracellular contents. The dithiolane ring of lipoic acid may also confer additional antioxidant activity. | Antimicrobial peptide research, Anti-drug-resistant bacteria (MRSA), Lipopeptide design, Membrane-active mechanism, Anti-infective drug screening, Anti-biofilm | Bacterial membrane (phosphatidylglycerol/LPS/lipoteichoic acid); lipoic acid dithiolane redox moiety |
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