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| Description | Cys(Npys)-(Arg)₉ is a tool peptide in which a cysteine residue activated with 3-nitro-2-pyridinesulfenyl (Npys) is added to the N-terminus of the nona-L-arginine ((Arg)₉) cell-penetrating peptide, with C-terminal amidation, sequence C(Npys)RRRRRRRRR-NH₂, CAS No. 1417221-06-7. Nonaarginine is one of the most efficiently penetrating members of the arginine oligomer family, carrying a net positive charge of +9 and efficiently entering cells through multiple mechanisms including macropinocytosis and direct translocation. The Npys-activated cysteine can undergo selective disulfide conjugation with free thiol-containing cargo (such as cysteine peptides, thiolated nucleic acids, thiolated small molecules) under mild conditions, forming disulfide linkages that can be cleaved by the intracellular reducing environment. This product is a commonly used reagent for constructing peptide-drug conjugates, nucleic acid delivery systems, and protein transduction tools. Note: This product is the L-arginine configuration, distinct from the D-arginine configuration Cys(Npys)-(D-Arg)₉. |
| Molecular formula | C₆₂H₁₁₈N₄₀O₁₂S₂ |
| Molecular weight (Da) | 1679.99 |
| Structure type | N-terminal Cys(Npys)-activated linear decapeptide (9 L-Arg), C-terminal amidated |
| Solubility | Freely soluble in water, PBS |
| Storage | Powder at -20°C, dry and protected from light; avoid contact with reducing agents |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Cys(Npys)-(Arg)9 | Npys-modified nonaarginine; thiol-reactive polyarginine peptide | Cell-penetrating peptide, site-specific chemical conjugation, nucleic acid/drug delivery, disulfide crosslinking | Nona-L-arginine N-terminally linked to Npys-modified cysteine; strong positively charged sequence efficiently penetrates cell membranes, Npys enables site-specific disulfide conjugation to drugs, proteins and nanocarriers | C₆₃H₁₃₀N₃₉O₁₀S₂ | 1677 | ~1678.6 | Acetate | 10 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-R09-Npys | Yellowish to off-white powder | Store at -20°C, sealed, dry and protected from light, under inert gas. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; protect from oxygen and light during shipping. | Stable for 7 days at 4°C. Strong cationic peptide is highly soluble in water, dilute acetic acid and acidic buffers. Npys group is sensitive to thiols and strong reducing agents; prone to disulfide exchange and inactivation. Avoid combination with reducing agents and thiol compounds. | Stable for 2 years at -20°C, dry, protected from light and under inert gas. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-R09-Npys | Npys-modified nonaarginine with dual strong penetration and site-specific thiol conjugation | Npys-modified nonaarginine is a bifunctional cell-penetrating peptide. The strong positively charged nonaarginine sequence efficiently penetrates cell membranes to deliver nucleic acids, proteins and small molecule drugs. The N-terminal Npys group provides a site-specific reactive site for disulfide exchange with thiols under mild conditions. | Gene transfection & gene therapy, protein drug conjugation, nanocarrier functionalization, site-specific chemical modification, CPP technology | Phospholipid bilayer; Npys-thiol conjugation site; electrostatic adsorption transmembrane transport |
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