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| Description | 3BP-3940 is a highly potent fibroblast activation protein (FAP)-targeting peptide with CAS number 2803421-14-7. This peptide is a 7-amino acid cyclic peptide cyclized via a disulfide bond between two cysteine residues, with one cysteine side chain modified with a DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) chelator via a tMeBn (trimethylbenzyl) linker, and an N-terminal n-butyl (nBu) and CAyl group modification. Fibroblast activation protein (FAP) is a type II transmembrane serine protease belonging to the prolyl oligopeptidase family. FAP is selectively overexpressed on the surface of cancer-associated fibroblasts (CAFs) in over 90% of human epithelial malignancies, while being almost absent in normal adult tissues, making it an ideal molecular target for tumor stroma-targeted imaging and therapy. 3BP-3940 is a high-affinity FAP-targeting peptide obtained through structural optimization and affinity maturation, capable of specifically binding to the enzymatic active site of FAP with nanomolar affinity. The DOTA chelator modified in 3BP-3940 is a macrocyclic polyamine polycarboxylic acid chelator capable of forming stable radionuclide complexes with various radionuclides (such as ⁶⁸Ga, ¹⁷⁷Lu, ⁹⁰Y, ⁶⁴Cu, etc.). When labeled with positron-emitting radionuclides such as ⁶⁸Ga, it can be used for PET (positron emission tomography) imaging diagnosis of FAP-positive tumors; when labeled with beta-emitting radionuclides such as ¹⁷⁷Lu, it can be used for peptide receptor radionuclide therapy (PRRT) of FAP-positive tumors. This "theranostic" design enables the same peptide molecule to be used for both diagnostic imaging and targeted therapy, achieving precision medicine. 3BP-3940 has been validated in clinical trials for its safety and efficacy in ⁶⁸Ga-PET imaging and ¹⁷⁷Lu radionuclide therapy, representing a leading molecule in FAP-targeted theranostics. This peptide is widely used in PET imaging diagnosis of FAP-positive tumors (including pancreatic cancer, colorectal cancer, breast cancer, lung cancer, etc.), peptide receptor radionuclide therapy, tumor stroma-targeted drug delivery, and FAP biology research. |
| Molecular formula | C₆₆H₉₈N₁₄O₁₈S₃ |
| Molecular weight (Da) | 1471.76 |
| Structure type | Cyclic heptapeptide (disulfide-cyclized, DOTA-chelated, FAP-targeting peptide / theranostic peptide) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder at -20°C, dry and protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| 3BP-3940 | SH3 domain-binding peptide 3BP-3940; Abl kinase regulatory peptide | Protein-protein interaction inhibitor, SH3 domain ligand, kinase signaling regulation, signaling pathway research | Proline-rich SH3 domain-binding peptide that specifically binds the SH3 domain of c-Abl tyrosine kinase, blocking SH3-mediated protein-protein interactions and downstream kinase signaling activation | C₆₅H₉₀N₁₂O₁₄ | 1266.67 | ~1267.8 | Acetate | 11 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-3BP-39 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in water, dilute acetic acid and PBS. Proline-rich structure enhances peptide rigidity and chemical stability. Structurally stable over a broad pH range. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-3BP-39 | 3BP-3940 proline-rich peptide blocks SH3 domain interactions to regulate kinases | 3BP-3940 is a specific SH3 domain-binding peptide with a proline-rich classical SH3 recognition motif. It binds the SH3 domains of tyrosine kinases such as c-Abl with high affinity, blocking SH3-mediated protein-protein interactions and kinase activation, for kinase signaling pathway research and anti-tumor target validation. | Kinase signaling research, protein-protein interactions, anti-tumor target validation, enzyme regulation research, peptide inhibitor development | Tyrosine kinase SH3 domain; proline-rich recognition motif; kinase signal transduction pathway |
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