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| Description | LyP-2 (CAS: 850859-24-4) is a 9-amino acid disulfide-cyclized peptide with the sequence Cys-Asn-Arg-Arg-Thr-Lys-Ala-Gly-Cys (CNRRTKAGC), where a disulfide bond is formed between Cys1 and Cys9, maintaining the peptide in a cyclic conformation. LyP-2 is a tumor lymphatic vessel-targeting peptide selected through in vivo phage display technology, which can specifically home to the lymphatic vessel system of various tumor models. The targeting properties of LyP-2 show significant tumor type heterogeneity: studies have shown that LyP-2 can target lymphatic vessels in C8161 melanoma and K14-HPV16 skin and cervical carcinomas, but not in MDA-MB-435 breast cancer tumors, indicating heterogeneity in lymphatic vessel molecular markers among different tumor types. The sequence of LyP-2 contains two consecutive arginines (Arg-Arg) and one lysine (Lys), providing positive charge, which may achieve targeted binding through interaction with specific receptors or molecules on the surface of lymphatic endothelial cells. Unlike the related LyP-1 peptide (sequence CGNKRTRGC, targeting p32 receptor/gC1qR), LyP-2 has a different sequence and targeting profile, suggesting it may bind to different lymphatic endothelial markers. Applications of LyP-2 include: (1) tumor lymphatic vessel imaging - after labeling with fluorescent dyes or radionuclides, for visualization of tumor lymphatic vessels and assessment of lymphatic metastasis; (2) tumor lymphatic-targeted drug delivery - targeted delivery of chemotherapeutic drugs, nanoparticles, or gene therapy reagents to tumor lymphatic vessels to inhibit tumor lymphatic metastasis; (3) tumor lymphatic vessel biology research - as a tool peptide to study molecular characteristics and heterogeneity of tumor lymphatic vessels; (4) tumor metastasis mechanism research - exploring the role of lymphatic vessels in tumor metastasis; (5) tumor prognosis assessment - tumor lymphatic vessel density and targetability correlate with tumor metastasis risk. LyP-2 is an important tool peptide for studying tumor lymphatic vessel biology and developing lymphatic-targeted theranostic strategies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| LyP-2 | Lymphoma-targeting peptide LyP-2; lymphoma-specific binding peptide | Lymphoma targeting, tumor-targeted delivery, lymphoma imaging, receptor-binding peptide | Lymphoma-specific heptapeptide screened by phage display; binds with high affinity to target receptors overexpressed on lymphoma cells, mediating targeted drug enrichment | C₃₅H₅₇N₁₁O₉ | 787.43 | ~788.0 | Acetate | 7 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-LYP02 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in water, dilute acetic acid and PBS. Optimal receptor binding activity at physiological pH; conformational change and binding activity loss under strong acid/base conditions. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-LYP02 | LyP-2 lymphoma-targeting peptide specifically binds lymphoma cells for targeted drug enrichment | LyP-2 is a lymphoma-specific targeting peptide screened by phage display. It binds with high affinity to characteristic receptors overexpressed on lymphoma cells, mediating targeted enrichment of conjugated chemotherapeutics, fluorescent imaging agents and nanoparticles in lymphoma tissue, enhancing efficacy and reducing systemic side effects. | Lymphoma targeted therapy, tumor targeted imaging, targeted drug development, hematologic oncology research, tumor molecular diagnosis | Lymphoma cell surface target receptor; receptor-mediated endocytosis; tumor-targeted enrichment |
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