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| Description | H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH (EPLQLKM, CAS: 683750-83-6) is a 7-amino-acid linear peptide with the sequence Glu-Pro-Leu-Gln-Leu-Lys-Met (EPLQLKM), featuring a free amino group at the N-terminus and a free carboxyl group at the C-terminus. The peptide contains one glutamic acid (Glu, acidic), one proline (Pro, conformational turn), two leucines (Leu, hydrophobic), one glutamine (Gln, polar), one lysine (Lys, basic), and one methionine (Met, hydrophobic sulfur-containing), with an overall isoelectric point of approximately 9.7, carrying a net positive charge under physiological pH conditions. The proline residue at position 2 introduces a conformational turn in the peptide backbone, influencing the overall three-dimensional conformation. The two leucines and one methionine provide hydrophobicity, potentially participating in interactions with protein hydrophobic pockets or lipid membranes. This peptide can serve as a tool peptide for protein-protein interaction studies, a model peptide for enzyme substrate recognition research, or as a building block for longer peptide sequences. The methionine residue requires attention to avoid oxidation (methionine sulfoxidation) during storage and use; storage under inert gas protection is recommended. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH | EPLQLKM heptapeptide; MMP substrate heptapeptide | Protease substrate peptide, metalloproteinase substrate, enzyme activity assay peptide, enzyme inhibitor screening | Linear heptapeptide Glu-Pro-Leu-Gln-Leu-Lys-Met with free C-terminal carboxylic acid; contains proline turn, hydrophobic leucine, positively charged lysine and methionine, serving as a specific cleavage substrate for matrix metalloproteinases (MMPs) | C₃₈H₆₇N₉O₁₁S | 857.47 | ~857.9 | Free peptide | 7 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-EPL07 | White powder | Store at -20°C, sealed, dry and protected from light, under inert gas. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; protect from oxygen during shipping. | Stable for 7 days at 4°C. Soluble in dilute acetic acid, PBS and DMSO. Methionine residue is sensitive to oxygen and prone to oxidative inactivation. Avoid prolonged exposure to air and oxidants. Peptide bonds prone to hydrolysis under strong alkaline conditions. | Stable for 2 years at -20°C, dry, protected from light and under inert gas. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-EPL07 | EPLQLKM heptapeptide as a specific substrate for MMP metalloproteinases | EPLQLKM is a specific substrate peptide for matrix metalloproteinases (MMP-2/MMP-9), containing the core MMP recognition and cleavage site. It is specifically cleaved by activated MMPs to generate detectable product fragments, and is used for quantitative MMP activity assays, enzyme kinetics studies, MMP inhibitor screening and efficacy evaluation. | Enzymology & inhibitor screening, tumor invasion research, tissue remodeling study, protease activity assay, drug discovery | Matrix metalloproteinases MMP-2/MMP-9; protease active site; enzymatic peptide bond cleavage site |
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