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| CAS | 157476-77-2 |
| Product name | CAS:157476-77-2:Lagatide |
| Sequence | His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly |
| Three letter sequence | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₁₄₈H₂₂₄N₄₀O₄₇ |
| Molecular weight (Da) | 3341.64 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Lagatide | Lagatide; [Gly2]-GLP-1(7-37); CAS 157476-77-2; GLP-1 receptor agonist | GLP-1 receptor agonist,Glucose-dependent hypoglycemia,Type 2 diabetes research,DPP-IV resistant,Endocrine regulatory peptide,Insulin secretion promotionrch | Histidine-Glycine-Glutamic acid-Glycine-Threonine-Phenylalanine-Threonine-Serine-Aspartic acid-Valine-Serine-Serine-Tyrosine-Leucine-Glutamic acid-Glycine-Glutamine-Alanine-Alanine-Lysine-Glutamic acid-Phenylalanine-Isoleucine-Alanine-Tryptophan-Leucine-Valine-Lysine-Glycine-Arginine-Glycine | C₁₄₈H₂₂₄N₄₀O₄₇ | 3340.62 | 3341.64 | Free amine, unmodified | Free carboxyl, unmodified | 31 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-LAG001 | white powder | Store at -20℃, protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 2 years sealed and dry at 2-8℃; prepare aqueous solutions freshly before use, aliquots stable for 1 month at -20℃ | Stable for 72 h at 4℃; despite DPP-IV resistance modification, it is still susceptible to tissue peptidase degradation. Avoid prolonged incubation in serum systems | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-LAG001 | Selective GLP-1 receptor agonist with glycine substitution at position 2 for improved DPP-IV resistance, promotes insulin secretion in a glucose-dependent manner, applied in type 2 diabetes mechanism research | Lagatide is a synthetic modified glucagon-like peptide-1 (GLP-1) analog. The substitution of alanine with glycine at position 2 significantly improves resistance to dipeptidyl peptidase IV (DPP-IV) degradation and prolongs in vivo half-life compared to native GLP-1. It binds with high selectivity to GLP-1 receptors on islet β-cell membranes, promotes insulin synthesis and secretion in a strictly glucose-dependent manner, inhibits excessive glucagon release, delays gastric emptying and reduces food intake, resulting in steady blood glucose lowering. With improved enzymatic stability and longer duration of action, it serves as a core tool molecule for type 2 diabetes pathogenesis research, GLP-1 receptor signaling pathway studies, and peptide hypoglycemic drug development. | Endocrine metabolism research,Type 2 diabetes research,GLP-1 signaling pathway research,Insulin secretion mechanism research,Peptide hypoglycemic drug development,Gastric emptying regulation research | Glucagon-Like Peptide-1 Receptor (GLP-1R); cAMP/PKA insulin secretion pathway; Gastric emptying regulatory pathway |
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