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| Product name | CAS:2269511-95-5:Anrikefon (Free base) |
| Development code | HSK21542, a highly selective peripherally-restricted kappa opioid receptor agonist with all-D-amino acid backbone for improved metabolic stability and negligible blood-brain barrier penetration. Applied in postoperative analgesia, CKD-associated pruritus and non-addictive analgesia mechanism research. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₃₉H₅₇N₇O₆ |
| Molecular weight (Da) | 723.92 |
| Salt form | Free base |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Anrikefon | Anrikefon free base; HSK21542 free base; CAS 2269511-95-5; Peripheral KOR agonist | Peripheral kappa opioid receptor agonist,Analgesic & antipruritic,Postoperative pain research,CKD pruritus research,Non-central opioid,Low addiction risk | D-Phenylalanine-D-phenylalanine-D-leucine-D-lysine-2-acetyl-2,7-diazaspiro[3.5]nonane (amide-linked, all-D-amino acid backbone) | C₃₉H₅₇N₇O₆ (free base) | 723.43 | 723.92 | Free amine, all-D-amino acid configuration | Amide-linked spiro ring, no free carboxyl | 4 (core peptide backbone with unnatural spiro terminus) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-ANR-F001 | white powder | Solid powder: store at -20℃, protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions recommended to be prepared in dilute acetic acid or DMSO | Stable for 72 h at 4℃; stable for 6 months at -80℃ in aliquots; stable for 1 month at -20℃ in aliquots. **Poor water solubility, slightly soluble in water**. Dissolve in dilute acetic acid, DMSO or methanol. Avoid strong acid/base to prevent amide bond hydrolysis | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ANR-F001 | Highly selective peripheral KOR agonist in free base form with no central side effects, applied in postoperative analgesia and CKD pruritus mechanism research | Anrikefon (development code HSK21542) is a highly selective peripherally-restricted kappa opioid receptor (KOR) agonist. Its core backbone is a peptide derivative with 4 D-amino acids, conjugated with a 2-acetyl diazaspiro ring at the C-terminus to significantly improve receptor affinity and peripheral selectivity, with negligible blood-brain barrier penetration. It binds with high selectivity to KOR in peripheral tissues, inhibits peripheral transmission of pain and itch signals, and exerts potent analgesic and antipruritic effects. With extremely low affinity to μ and δ opioid receptors, it avoids the addiction, respiratory depression, constipation and nausea of traditional central opioids. The free base is the pharmacologically active form, suitable for formulation development, salt form screening and pharmacological mechanism research, and serves as a core tool molecule for pain and pruritus mechanism research and novel non-addictive analgesic development. | Pain pharmacology research,Postoperative analgesia research,CKD pruritus research,Opioid receptor pathway research,Non-addictive analgesic development,Peripheral nerve signaling research | Kappa Opioid Receptor (KOR); Peripheral nociceptive signaling pathway; Itch signaling pathway |
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