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| Product name | CAS:78113-36-7:Romurtide |
| Description | Romurtide is a second-generation lipophilic muramyl dipeptide (MDP) derivative. It activates innate immunity and the hematopoietic system, promotes leukocyte production, and is applied in adjuvant therapy for chemotherapy-induced leukopenia, immunocompromised states and immune mechanism research. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₃₅H₆₃N₇O₁₂ |
| Molecular weight (Da) | 741.92 |
| Modification type | Muramyl modification + side-chain stearoylation |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Romurtide | Romurtide; MDP-Lys(L18); Stearoyl muramyl tripeptide; CAS 78113-36-7 | Immune enhancement,Hematopoietic promotion,Leukopenia,Macrophage activation,Muramyl dipeptide derivative,Chemotherapy adjuvant immunity | N-Acetylmuramic acid-alanine-isoglutamine-lysine (side-chain stearoylation) | C₃₅H₆₃N₇O₁₂ | 741.45 | 741.92 | N-terminal muramyl blocked, no free amine | Isoglutamine side-chain amide | 3 amino acids + sugar + fatty acid side chain |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-ROM001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid high temperature and humidity | Solid powder stable for 1 year at 2-8℃ sealed and dry; stock solutions prepared in DMSO | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Poor water solubility, DMSO or anhydrous ethanol required**. Prone to form suspension in aqueous phase; ester and peptide bonds easily hydrolyzed under acid/base | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ROM001 | Lipophilic muramyl dipeptide derivative that activates innate immunity and promotes hematopoiesis, elevates post-chemotherapy leukocyte levels | Romurtide is a second-generation immunomodulator optimized by introducing a lysine stearoyl side chain on the muramyl dipeptide backbone. Stearoyl modification significantly enhances cell permeability and in vivo half-life. It specifically binds to NOD2 receptors on macrophages and monocytes, activates innate immune pathways, promotes release of cytokines such as IL-1, TNF-α and CSF, and further stimulates proliferation and differentiation of bone marrow hematopoietic stem cells, significantly increasing peripheral blood neutrophil and monocyte counts. Clinically used as adjuvant therapy for radiotherapy/chemotherapy-induced leukopenia to reduce infection risk, it also serves for immune reconstitution in immunocompromised states, innate immunity mechanism research and vaccine adjuvant development. | Chemotherapy adjuvant research,Leukopenia research,Innate immunity mechanism study,Vaccine adjuvant development,Hematopoietic regulation research,Infection immunity research | NOD2 Receptor; Innate immune activation pathway; Hematopoietic stem cell proliferation and differentiation pathway |
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