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| Product Name | TRV-120027 TFA |
| Description | TRV-120027 is a classic β-arrestin-biased agonist of the AT₁ receptor. It specifically binds to the AT₁ receptor and induces a specific conformational change, selectively activating the downstream β-arrestin-mediated signaling pathway to promote cardiomyocyte survival, inhibit apoptosis and ameliorate cardiac remodeling, without activating traditional G protein-dependent effects such as vasoconstriction and blood pressure elevation. It exhibits definite cardioprotective and cardiac function-improving effects in models of heart failure, myocardial ischemia-reperfusion injury and cardiac hypertrophy, without obvious hypertensive side effects. It is a core tool peptide for studying biased signal transduction of G protein-coupled receptors and cardiovascular protection mechanisms, and is also widely used in the development of novel biased cardiovascular drugs. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Free base molecular formula | C₅₁H₇₃N₁₃O₁₂ |
| Free base molecular weight (Da) | 1060.2, higher for TFA salt form |
| Structure type | Modified octapeptide with β-arrestin-biased design, trifluoroacetate salt |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| TRV-120027 TFA | TRV-120027 trifluoroacetate | AT₁ receptor β-arrestin-biased agonist, cardioprotection, GPCR biased signaling research | Functional octapeptide site-modified from angiotensin II backbone; selectively activates β-arrestin pathway downstream of AT₁R without activating G protein-dependent vasoconstrictive pathway | C₅₁H₇₃N₁₃O₁₂ | 1059.55 | 1060.2 | Trifluoroacetate (TFA) | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-TRV001 | white powder | Store at -20°C, sealed, dry and protected from light. Aliquot to avoid repeated freeze-thaw cycles. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack recommended. | Stable for 7 days at 4°C. Moderate water solubility, assisted by dilute acetic acid or acidic buffer; freely soluble in DMSO. Aqueous solution is susceptible to peptidase degradation; prepare fresh before use. | Stable for 3 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-TRV001 | AT₁ receptor β-arrestin-biased agonist with targeted cardioprotection and no hypertensive side effect | TRV-120027 is a classic β-arrestin-biased agonist of the angiotensin II type 1 receptor (AT₁R). It specifically binds to the AT₁ receptor and induces a specific conformational change, selectively activating the downstream β-arrestin-mediated signaling pathway to promote cardiomyocyte survival, inhibit apoptosis, ameliorate cardiac remodeling and reduce myocardial fibrosis. Meanwhile, it does not activate traditional G protein-dependent effects such as vasoconstriction and blood pressure elevation, avoiding the hypertensive side effects of conventional AT₁ agonists. It exhibits definite cardioprotective and cardiac function-improving effects in models of heart failure, myocardial ischemia-reperfusion injury and cardiac hypertrophy. It is a core tool peptide for studying biased signal transduction of G protein-coupled receptors and cardiovascular protection mechanisms, and is also widely used in the development of novel biased cardiovascular drugs. | GPCR biased signaling research, heart failure mechanism study, myocardial ischemia-reperfusion injury research, cardiac remodeling & fibrosis study, cardiovascular drug development | Angiotensin II type 1 receptor (AT₁R); β-arrestin signaling pathway; Cardiomyocyte survival pathway |
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