Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of β-amyloid (1-28) cas 109770-29-8 in China, also supports custom service. Welcome to wholesale bulk high quality β-amyloid (1-28) cas 109770-29-8 from our factory. Contact us for more details.
| Product name | CAS:109770-29-8;β-Amyloid (1-28) |
| Sequence | DAEFRHDSGYEVHHQKLVFFAEDVGSNK |
| Three letter sequence | Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C145H209N41O46 |
| Molecular weight (Da) | 3262.51 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| β-Amyloid (1-28) | #Aβ(1-28); CAS 109770-29-8; Aβ1-28; Alzheimer's disease model peptide; Soluble Aβ fragment | Alzheimer's disease, Aβ oligomer aggregation, Neurotoxicity, Synaptic impairment, Amyloid plaque precursor, Neurodegeneration, Microglia activation, Peptide aggregation kinetics | Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asp-Gly | C₁₄₀H₂₁₀N₄₄O₄₇ | 3231.52 | 3233.37 | Free amine, unmodified | Free carboxyl, unmodified | 28 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-Aβ28001 | White powder | -20°C, sealed light-proof packaging, aliquot to avoid repeated freeze-thaw; Long-term stock recommended to aliquot & lyophilize from HFIP | 2~8°C, use within 7 days, prepare fresh each experiment, do not store aqueous solution long term | Stable for 12 h at 4°C in dilute acetic acid; Slow spontaneous oligomerization occurs over time | Stable for 2 years at -20°C |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-Aβ28001 | Aβ(1-28) is soluble N-terminal core fragment of full-length Aβ, retains complete hydrophilic domain, readily forms oligomers to trigger neuronal toxicity & microglial inflammation, canonical tool peptide for Alzheimer's aggregation mechanism research | β-Amyloid (1-28) is a 28-residue soluble fragment cleaved from Amyloid Precursor Protein (APP). It lacks the highly hydrophobic C-terminal transmembrane segment, exhibiting superior aqueous solubility vs Aβ1-40/Aβ1-42 and enabling controllable in-vitro oligomerization. Core bioactivities: 1. Neurotoxicity: Oligomeric Aβ1-28 binds synaptic membrane receptors to disrupt synaptic plasticity, induce oxidative stress and trigger neuronal apoptosis; 2. Pro-inflammatory activation: Stimulates microglia to secrete pro-inflammatory cytokines TNF-α, IL-1β, amplifying neuroinflammatory cascades; 3. Aggregation model reagent: Widely applied to study Aβ folding, oligomerization, fibrillization kinetics and screen anti-aggregation therapeutic compounds; 4. AD pathological simulation: Construct in-vitro cellular Alzheimer's models to investigate Aβ-mediated memory impairment and blood-brain barrier permeability alteration. Widely used in neurodegenerative pharmacology, Alzheimer's disease pathogenesis, amyloid peptide aggregation, synaptic biology, microglial neuroinflammation and anti-AD drug screening | Neurodegenerative pharmacology, Alzheimer's disease models, Amyloid peptide aggregation kinetics, Neuronal synaptic damage, Microglial inflammation, Anti-amyloid drug screening, Oxidative stress neuroinjury | Neuronal membrane receptors NMDA, PrP^C; Microglial TLR4 inflammatory signaling pathway |
Hot Tags: β-amyloid (1-28) cas 109770-29-8, China β-amyloid (1-28) cas 109770-29-8 manufacturers, suppliers, factory, Amyloid 1 34 , Amyloid 1 8 CAS 659739 33 0, Amyloid 10 20 , 152286-31-2, 190436-05-6, 659739-33-0
