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| Description | DAEFRHDSGYEVHHQK (residues 1–17) with His metal-binding sites and no hydrophobic core; largely non-aggregating, used for Cu/Zn binding, N-terminal conformation and antibody studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure (Sequence) | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| β-Amyloid (1-17), human (Aβ residues 1–17, 17-mer, DAEFRHDSGYEVHHQKL) | Aβ(1-17); Amyloid β(1-17); DAEFRHDSGYEVHHQKL; N-terminal Aβ fragment; β-Amyloid (1-17) | β-amyloid N-terminal fragment, Aβ N-terminal antigen epitope, Alzheimer's disease (AD), antibody recognition, ELISA/biomarker, histidine cluster, short synthetic peptide | Linear 17-mer, sequence DAEFRHDSGYEVHHQKL (residues Asp1–Leu17 of human Aβ 1-42); N-terminal Asp free α-amino, C-terminal Leu free α-carboxyl; covers the highly conserved N-terminal domain of Aβ; contains acidic residues (D1, E3, D7, E11), histidine cluster (H6, H13, H14), Arg5 and Lys16; N-terminal acidic region confers good water solubility; net charge approx. −2. | C90H130N28O29 | 2066.96 | 2068.20 | Free acid / Acetate salt; CAS 186319-72-2 | 17 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BAβ1-17-01 | White powder | Store at −20°C, sealed, desiccated, protected from light; recommend aliquoting to avoid repeated freeze-thaw cycles; stable for ~2 years. | 2–8°C for up to ~1–2 weeks; working aliquots at −20°C or −80°C; avoid repeated room-temperature thawing. | N-terminally enriched in acidic residues (Asp, Glu) and a histidine cluster; good water solubility. Dissolve directly in ultrapure water or PBS (pH 7.4); dilute ammonia or acetic acid may be used to adjust pH if needed. Relatively stable in solution; prepare fresh or aliquot and store at −80°C; avoid prolonged room-temperature storage. | White solid stable for ~2 years at −20°C, sealed and desiccated; contains His/Tyr residues; keep dry and protected from light; avoid repeated freeze-thaw. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-BAβ1-17-01 | Human Aβ(1-17) 17-mer DAEFRHDSGYEVHHQKL covering the highly conserved N-terminal antigen-epitope region with a histidine cluster; good water solubility; for AD N-terminal antibody recognition, ELISA biomarker and immunological epitope research; white powder, stored at −20°C. | Amyloid-β (Aβ) is the major protein component of senile plaques in Alzheimer's disease (AD) brain. Aβ(1-17) (DAEFRHDSGYEVHHQKL) covers the highly conserved N-terminal domain (residues 1–16 are the well-recognized N-terminal antigen-epitope region), encompassing clinically important antibody recognition sites such as the 6E10 epitope (E3–D7) and anti-Aβ N-terminal antibodies targeting Asp1. The histidine cluster (H6, H13, H14) participates in Cu²⁺ binding and redox homeostasis, contributing to Aβ neurotoxicity. This fragment lacks the central hydrophobic core (LVFF begins at residue 17) and the C-terminal transmembrane hydrophobic region, so it is weakly aggregating and highly soluble-an ideal reagent for: (1) N-terminal-specific anti-Aβ antibody production and epitope mapping immunogen; (2) coating peptide/reference standard in ELISA, Western blot and IHC to discriminate N-terminal-epitope antibodies; (3) method development for CSF Aβ biomarker immunoassays; (4) substrate for studying N-terminal post-translational modifications (e.g., pyroglutamate pE3, phospho-S8) and cleavage by Aβ-degrading enzymes (NEP/IDE); (5) vaccine and immunological epitope research. Chemically synthesized, >95% pure (HPLC). | Alzheimer's disease (AD), Aβ N-terminal antigen epitope, anti-Aβ antibody generation & epitope mapping, 6E10 / N-terminal antibody recognition, ELISA/immunoassay biomarker, histidine cluster Cu binding, Aβ PTMs (pE3/pS8), vaccine/immunological epitope research | Aβ conserved N-terminal epitope (Asp1–Leu17); 6E10 and anti-Aβ N-terminal mAb recognition region; histidine-cluster Cu-binding site; NEP/IDE degradation substrate region |
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