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| Description | DAEFRH with blocked termini to remove terminal-charge interference; Aβ1-6 contains an N-terminal antibody-recognition epitope, used to study epitope conformation and antibody binding. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure (Sequence) | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Acetyl-Amyloid β-Protein (1-6) amide (N-acetylated, C-amidated human amyloid-β 1–6, 6-mer, Ac-DAEFRH-NH₂) | Ac-Aβ(1-6)-NH₂; Acetyl-Aβ1-6 amide; Ac-DAEFRH-NH₂; CAS 903883-22-7 | Aβ N-terminal short peptide, N-acetylation & C-amidation, B-cell epitope, AD vaccine, immunogen, antibody epitope mapping, metal-ion binding, Alzheimer's disease | Linear 6-mer, Ac-DAEFRH-NH₂; N-terminal α-amino acetylated (Ac-, blocking the amine, increasing hydrophobicity and protease resistance) and C-terminal carboxyl amidated (-NH₂, neutralizing negative charge); sequence Asp-Ala-Glu-Phe-Arg-His with three acidic residues (Asp1, Glu3) plus one Arg and one His, overall acidic and charged; Phe4 is the sole hydrophobic residue. Terminal blocking makes it charge-neutral at the ends and resistant to aminopeptidase/carboxypeptidase, mimicking a stable B-cell epitope conformation. | C35H50N12O11 | 814.37 | 814.85 | Free base / ammonium (N-acetylated & C-amidated) | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-AcAB16-01 | White powder | Store at −20°C, sealed, desiccated, protected from light; aliquot to avoid repeated freeze-thaw, ~2 years. The short peptide is fairly stable, but keep dry and light-protected. | 2–8°C for ~2–4 weeks; working aliquots at −20°C or −80°C; avoid prolonged room-temperature exposure. | Short peptide with moderate-to-good water solubility (multiple charged residues Asp/Glu/Arg/His); readily dissolved in water or PBS/neutral buffer; due to terminal blocking and slightly increased hydrophobicity, a small amount of DMSO may be used first if needed before aqueous dilution. In solution keep at 4°C for ~1 week or aliquot at −20°C; avoid repeated freeze-thaw; this peptide does not aggregate and needs no HFIP pre-treatment. | solid stable for ~2 years at −20°C, sealed, desiccated and light-protected; hygroscopic-keep dry and light-protected. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-AcAB16-01 | N-acetylated, C-amidated human Aβ(1-6) blocked short peptide Ac-DAEFRH-NH₂, corresponding to the most N-terminal immunodominant B-cell epitope of Aβ; used for AD vaccine/therapeutic-antibody epitope mapping, immunogen conjugation and Cu/Zn metal-ion binding studies; white powder, water-soluble, −20°C aliquot storage. | Aβ(1-6) (DAEFRH) lies at the very N-terminus of amyloid-β and is one of the most immunodominant B-cell epitopes of Aβ, as well as the target region of many active AD immunization vaccines (mimicking the N-terminal epitope) and passive therapeutic antibodies (recognizing the N-terminal conformation). Acetylating the N-terminal α-amino group and amidating the C-terminal carboxyl group neutralize terminal charges, confer resistance to aminopeptidases and carboxypeptidases, and better mimic the epitope conformation as presented on full-length Aβ / amyloid fibrils, making it a standardized short peptide for precise anti-Aβ antibody epitope mapping, vaccine immunogen design, and ELISA / competitive-binding assays. This N-terminal segment is also rich in histidine (His6) and acidic residues (Asp1, Glu3), constituting one of the main coordination regions for Aβ binding to transition metal ions such as Cu²⁺ and Zn²⁺, and can be used to study metal-ion–Aβ interactions, metal-induced aggregation and oxidative stress. Being short and lacking the C-terminal hydrophobic aggregation core, this peptide itself does not form amyloid fibrils; it is commonly used as an N-terminal-specific control or epitope peptide to distinguish N-terminal- from central/C-terminal-directed antibodies, and as a detection epitope for measuring antibody titers in AD vaccine clinical trials. | Alzheimer's disease (AD) vaccine / active immunization, therapeutic-antibody epitope mapping, ELISA / competitive-binding assays, immunogen conjugation, Cu/Zn metal-ion–Aβ coordination, antibody titer measurement | Aβ N-terminal B-cell epitope (DAEFRH); recognized by anti-Aβ N-terminal therapeutic antibodies; His/Asp/Glu residues mediate Cu/Zn metal-ion binding |
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