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| Description | The epitope recognized by humanized anti-Tac (anti-CD25/IL-2Rα, daclizumab-like); used for IL-2Rα interactions, transplant immunity and Treg studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Humanized anti-Tac (HAT) binding peptide | HAT binding peptide, EPIHRSTLTALL, CAS 223744-37-4, anti-IL-2Ralpha/CD25 antibody Fc-binding peptide, daclizumab-related affinity peptide | Antibody affinity peptide, HAT/humanized anti-Tac, IL-2Ralpha/CD25, affinity chromatography, mAb purification, phage-display peptide | H-Glu-Pro-Ile-His-Arg-Ser-Thr-Leu-Thr-Ala-Leu-Leu-OH (12-aa linear peptide, free N-term/C-term; phage-display-selected Fc-region-binding peptide of HAT; no Cys/Met/Trp/Tyr; net charge +1: 1 Arg + 1 His - 1 Glu) | C60H103N17O18 | 1349.77 | 1350.59 | TFA salt (typical) | 12 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-HAT-01 | White to off-white powder (standard synthetic peptide) | Store frozen below -20°C, dry and sealed (powder 3 years); TFA salt is hygroscopic - keep dry and sealed; store in solution at -80°C for ~1 year; avoid repeated freeze-thaw | Store sealed and dry at 2-8°C, use within 2-4 weeks; after reconstitution, aliquot and store below -20°C | Moderately hydrophilic (net charge +1: 1 Arg, 1 His, 1 Glu) with several hydrophobic residues (Ile/Leu×3/Ala); pre-wet with a small amount of DMSO or dilute acetic acid then dilute with PBS/water; TFA salt is hygroscopic - weigh and reconstitute promptly; no photo-/oxidation-sensitive residues - routine light protection suffices | powder stable for ~3 years at -20°C when dry and sealed; TFA salt is hygroscopic - keep in a desiccator; aliquot promptly after opening |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-HAT-01 | 12-aa Fc-region-binding peptide (sequence EPIHRSTLTALL, CAS 223744-37-4) for humanized anti-Tac (HAT, anti-IL-2Ralpha/CD25, daclizumab-related); used to develop affinity-chromatography media for mAb purification and in antibody-antigen interaction studies. | anti-Tac is a murine monoclonal antibody against the low-affinity p55 subunit of the human IL-2 receptor (IL-2Ralpha, Tac/CD25); humanized anti-Tac (HAT) is the daclizumab-related humanized antibody. This product is a 12-aa peptide (EPIHRSTLTALL, CAS 223744-37-4; formula C60H103N17O18, supplier MW 1350.56) selected by phage display to specifically bind the Fc region of HAT. Rather than being derived from IL-2Ralpha itself, it is an affinity ligand directed against the HAT antibody, used to build affinity-chromatography media for purifying specific mAbs, to study antibody Fc-region interactions, and for structure-function and immunoassay development of IL-2Ralpha/CD25-targeting antibodies. Suppliers (AdooQ / TargetMol / MCE) list the same sequence and CAS. | Antibody purification, affinity-chromatography media development, mAb drug R&D, IL-2Ralpha/CD25 targeting, antibody Fc interactions, immunoassay development | Fc region of HAT/humanized anti-Tac antibody (daclizumab-related); IL-2Ralpha (CD25/Tac)-targeting antibody |
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