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| Description | Mouse cardiac Myhc-α residues 334–352, the canonical immunodominant EAM-inducing peptide; EAM models human myocarditis/dilated cardiomyopathy. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Myhc-alpha (334-352) (mouse cardiac myosin heavy chain alpha) | Cardiac myosin heavy chain alpha 334-352 peptide, CAS 171675-09-5, DSAFDVLSFTAEEKAGVYK, I-Ak-restricted CD4 epitope | Autoantigen epitope, cardiac myosin, experimental autoimmune myocarditis, EAM, CD4+ T-cell epitope, MHC-II | H-Asp-Ser-Ala-Phe-Asp-Val-Leu-Ser-Phe-Thr-Ala-Glu-Glu-Lys-Ala-Gly-Val-Tyr-Lys-OH (linear 19-mer, free N-terminal H and C-terminal OH; no Cys/Met/Trp; contains 1 Tyr) | C94H141N21O32 | 2076.01 | 2077.28 | TFA salt (typical) | 19 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-MYHC-01 | White to off-white powder (TFA salt is hygroscopic - reseal immediately after opening) | Store sealed, dry and protected from light at -20°C (contains 1 Tyr - protect from light); aliquot into single-use portions and avoid repeated freeze-thaw; stable for ~2 years; keep TFA salt in a desiccator | Store sealed, dry and protected from light at 4°C, use within 2-4 weeks; after reconstitution, aliquot and store below -20°C protected from light | Moderately hydrophilic (2 Asp, 2 Glu, 2 Lys; near-neutral net charge); soluble in water or PBS (pH 7.4); if needed, wet with a small amount of dilute acetic acid or sonicate to aid dissolution; prepare fresh, stable ~1 week at 4°C protected from light; contains Tyr - protect from light during handling and storage | powder stable for ~2 years below -20°C when sealed, dry and protected from light; protect from moisture and light; aliquot promptly after opening and keep in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-MYHC-01 | 19-aa peptide corresponding to residues 334-352 of mouse cardiac myosin heavy chain alpha (MyHC-alpha, MYH6; DSAFDVLSFTAEEKAGVYK, CAS 171675-09-5); an I-Ak-restricted CD4+ T-cell epitope that induces experimental autoimmune myocarditis (EAM) in A/J mice. | Residues 334-352 of cardiac myosin heavy chain alpha (MyHC-alpha; human MYH6 UniProt P13533 / mouse MYH6 Q02566), sequence DSAFDVLSFTAEEKAGVYK, is a well-characterized pathogenic CD4+ T-cell epitope in H-2k (I-Ak) mice. Immunization of A/J mice with this peptide induces experimental autoimmune myocarditis (EAM), making it a key autoantigen peptide for studying the mechanisms of autoimmune myocarditis and dilated cardiomyopathy. The peptide carries a free N-terminal amino group and free C-terminal carboxyl (no N-terminal acetylation), contains no Cys/Met/Trp and contains one Tyr (protect from light). It is used for EAM induction, detection of MyHC-alpha-specific CD4+ T cells (proliferation / ELISpot / intracellular cytokine staining), I-Ak tetramer staining, and studies of TCR recognition and cardiac autoimmune tolerance. Source: mouse cardiac myosin heavy chain alpha (MYH6). | Autoimmune myocarditis, EAM model, dilated cardiomyopathy, cardiac immunology, CD4+ T-cell epitope detection, MHC-II antigen presentation | I-Ak (MHC class II) presentation; MyHC-alpha-specific CD4+ T cells; T-cell receptor (TCR) |
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