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| Description | EGFR intracellular juxtamembrane residues 985–996, containing key tyrosine autophosphorylation/regulation sites; used for EGFR signaling, phospho-antibody recognition and autoregulation. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Epidermal Growth Factor Receptor Peptide (985-996) (EGFR C-terminal residues 985-996 dodecapeptide) | EGFR Peptide (985-996), DVVDADEYLIPQ, Kris et al. Cell 1985 peptide 2E, anti-EGFR C-terminal immunizing peptide, H-Asp-Val-Val-Asp-Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-OH | EGFR C-terminal peptide, Tyr992 autophosphorylation site, anti-EGFR antibody production, A431 calpain cleavage, Tyr-containing (light-protected), net charge -4, water-soluble | H-Asp-Val-Val-Asp-Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-OH (DVVDADEYLIPQ, linear 12-mer, free N-terminal amino group and free C-terminal carboxyl; contains 1 Tyr corresponding to an autophosphorylation site, no Cys/Met) | C61H93N13O23 | 1375.65 | 1376.48 | Not specified (commercial product is acetate salt; per Certificate of Analysis) | 12 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-EGFR985-01 | White solid | Store desiccated and sealed below -20°C, protected from light; powder stable for ~3 years; reconstituted aliquots protected from light stored at -20°C/-80°C | Use short-term at 4°C sealed, desiccated and protected from light within 2-4 weeks; after reconstitution, aliquot and freeze, avoid repeated freeze-thaw | Net charge ~-4 (Asp x3 and Glu x1), negatively charged and water-soluble; can be reconstituted directly in water-if difficult, first dissolve in a small amount of DMSO then dilute with water/PBS; contains 1 Tyr (potential autophosphorylation site), keep protected from light; no Cys/Met, so no additional antioxidation/deoxygenation requirement | White solid, stable for ~3 years at -20°C when desiccated, light-protected and sealed; protect from moisture and light; aliquot promptly after opening and keep in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-EGFR985-01 | The C-terminal 985-996 dodecapeptide DVVDADEYLIPQ of the epidermal growth factor receptor (EGFR; the literature 'peptide 2E'), containing the classical Tyr992 autophosphorylation site; used to raise anti-EGFR C-terminal antibodies and in receptor cleavage/signaling studies. | This peptide corresponds to the cytoplasmic C-terminal 12-mer DVVDADEYLIPQ of the epidermal growth factor receptor (EGFR/ErbB1), i.e. the 'peptide 2E' reported by Kris et al. (Cell, 1985). This segment contains the classical autophosphorylation site Tyr992 and can serve as an immunogen to raise antibodies specific for the EGFR C-terminal cytoplasmic domain, as well as to study the calpain-generated cleavage fragments of EGFR in A431 cells. Note on numbering: 985-996 follows the early literature numbering and corresponds to residues 1009-1020 of UniProt P00533 (human EGFR, full-length 1186 aa). Order by the sequence DVVDADEYLIPQ and CAS 96249-43-3 (commercial product commonly supplied as acetate salt). | Receptor tyrosine kinase, EGFR signal transduction, antibody immunogen, autophosphorylation site studies, proteolysis / cleavage analysis | EGFR (ErbB1/HER1) C-terminal cytoplasmic domain; Tyr992 autophosphorylation site; anti-EGFR C-terminal antibodies |
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