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| Description | Brain Derived Basic Fibroblast Growth Factor (1–24) (CAS: 211362-85-5, bFGF/FGF-2 1-24) is a 24-residue synthetic fragment corresponding to residues 1-24 of human basic fibroblast growth factor (bFGF, FGF-2), sequence PALPEDGGSGAFPPGHFKDPKRLY. Molecular formula C118H173N31O33, MW 2553.86 Da. This fragment covers the N-terminal heparin/FGFR-binding core of the full-length 155-aa bFGF, retaining key epitopes for FGF receptor (FGFR) and heparan sulfate proteoglycan interactions. It is used to study FGF signaling, cell proliferation, angiogenesis, and neurogenesis as the minimal functional bFGF epitope. |
| Structure type | Linear 24-mer (human bFGF/FGF-2 N-terminal 1-24 receptor-binding fragment) |
| Solubility | Readily soluble in DMSO (100 mg/mL), water |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Brain Derived Basic Fibroblast Growth Factor (1-24) | bFGF (1-24); FGF basic (1-24); FGF-2 (1-24); N-terminal 1-24 peptide of basic FGF; PALPEDGGSGAFPPGHFKDPKRLY; CAS 211362-85-5; HBGF-2 N-terminal fragment | growth factor fragment, heparin-binding domain peptide, bFGF/FGF-2 N-terminal peptide, mitogen fragment, anti-HBV replication, endothelial cell migration, non-antimicrobial, Pro/Gly-rich flexible peptide | Linear 24-aa peptide, sequence PALPEDGGSGAFPPGHFKDPKRLY (Pro-Ala-Leu-Pro-Glu-Asp-Gly-Gly-Ser-Gly-Ala-Phe-Pro-Pro-Gly-His-Phe-Lys-Asp-Pro-Lys-Arg-Leu-Tyr), corresponding to residues 1-24 of human/bovine basic fibroblast growth factor (bFGF/FGF-2, a 146-aa heparin-binding growth factor); free N-terminal Pro amine and free C-terminal Tyr carboxyl; 3 acidic residues (E5/D6/D19) balanced by 3 basic residues (K18/K21/R22) plus 1 His (H16), net charge near neutral (~0) at pH 7.4; 5 Pro (P1/P4/P13/P14/P20) and 4 Gly (G7/G8/G10/G15) confer high conformational flexibility, no canonical alpha-helix; the C-terminal cluster K18-D19-P20-K21-R22 forms a basic heparin-binding motif; no Cys, no Met, no Trp, only 1 Tyr (Y24) | C118H173N31O33 | 2552.28 | 2553.87 | Free peptide; no salt form | 24 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-FGFB24-01 | White powder | Store at -20°C, desiccated and sealed; no Cys/Met/Trp oxidation-sensitive residues, chemically stable; contains 1 Tyr so mildly light-sensitive, protect from light; conventional sealing suffices, no argon flush needed | 2-8°C, desiccated, stable for weeks to months | Moderate water solubility: balanced acidic/basic residues but contains a basic heparin-binding cluster; soluble in water or PBS; prepare fresh, store aqueous solutions at 4°C for no more than 1 week; avoid repeated freeze-thaw; protect from light due to Tyr | solid is stable, no significant oxidative degradation risk; store dry and sealed |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-FGFB24-01 | Synthetic N-terminal 1-24 fragment of bFGF/FGF-2 (146-aa heparin-binding growth factor), retaining the K18-K21-R22 heparin-binding basic cluster; Pro/Gly-rich flexible peptide that inhibits HBV replication and endothelial cell migration, a tool peptide for studying bFGF receptor/heparin interactions. | Basic fibroblast growth factor (bFGF/FGF-2/HBGF-2) is a 146-aa heparin-binding growth factor isolated in the 1970s from bovine pituitary and brain tissue, a member of the FGF family with broad mitogenic, angiogenic, tissue-repair and neuroprotective activities. bFGF signals by binding and activating FGF receptor tyrosine kinases (e.g., FGFR1c), and high-affinity heparin/heparan sulfate binding is essential for receptor dimerization and signaling. Brain Derived Basic Fibroblast Growth Factor (1-24) is the synthetic peptide corresponding to N-terminal residues 1-24 of bFGF, sequence PALPEDGGSGAFPPGHFKDPKRLY, identical between human and bovine bFGF. This fragment contains the N-terminal heparin-binding basic cluster (Lys18-Asp19-Pro20-Lys21-Arg22) and partially retains heparin/FGFR interaction capacity, though as a free short peptide its mitogenic activity is far lower than full-length bFGF. Studies show this 24-mer inhibits hepatitis B virus (HBV) replication in HepG2.2.15 cells at 10 microg/mL and suppresses human endothelial cell migration after 22 h treatment, suggesting it interferes with bFGF-heparin/FGFR interactions or downstream signaling to exert antiviral and anti-angiogenic effects. Its Pro-rich (5) and Gly-rich (4) composition prevents a canonical alpha-helix, instead adopting a flexible extended conformation consistent with the disordered N-terminus seen in full-length bFGF crystal structures. This product is widely used for bFGF functional-domain mapping, heparin-binding peptide screening, FGFR antagonist development, and structure-activity studies of anti-HBV and anti-angiogenic peptides. | growth factor functional domain research, heparin-binding peptide screening, FGFR signaling, anti-HBV drug research, angiogenesis/endothelial cell migration, bFGF structure-activity relationship, peptide drug design | Heparin/heparan sulfate binding domain; FGFR receptor interaction (partial); HBV replication (HepG2.2.15 model); endothelial cell migration |
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