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| Description | Drosocin (CAS: 149924-99-2) is a 19-residue proline-rich cationic antimicrobial peptide isolated from Drosophila melanogaster, sequence GKPRPYSPRPTSHPRPIRV. Molecular formula C₉₈H₁₆₀N₃₄O₂₄, MW 2198.53 Da. Native drosocin carries an O-linked disaccharide moiety attached to a mid-chain threonine residue; this glycosylation is required for maximal activity, and the unglycosylated synthetic peptide shows significantly reduced activity. Drosocin binds the bacterial ribosome and inhibits protein synthesis, belonging to the Pro-rich AMP family together with apidaecin and pyrrhocoricin. Drosocin is a classic member for studying insect innate immunity, ribosome-targeting AMPs, and glycosylated AMP design. |
| Structure type | Linear 19-mer (Pro-rich; native Thr O-glycosylation) |
| Solubility | Readily soluble in water, dilute acetic acid |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Drosocin | Drosophila antimicrobial peptide; proline-rich drosocin | Antimicrobial peptide, Gram-negative targeting, proline-rich, chaperone inhibition, insect immunity | Proline-rich antimicrobial peptide induced by Drosophila immunity, with a linear extended conformation and high proline/arginine content; exerts bactericidal effects by binding bacterial DnaK and inhibiting protein folding | C₈₉H₁₄₇N₃₁O₂₄ | 2076.12 | ~2077.5 | Acetate | 19 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-DROS19 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in dilute acetic acid and acidic buffers. High proline content confers high thermostability and protease resistance; tolerates short-term high temperature. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-DROS19 | Drosocin fly peptide targeting Gram-negative bacteria | Drosocin is a proline-rich AMP induced in Drosophila innate immunity, forming a unique extended conformation with high proline and arginine content. It penetrates the bacterial outer membrane into the cytoplasm, binds the molecular chaperone DnaK and inhibits its ATPase activity, blocking bacterial protein folding and assembly. It exerts potent bactericidal effects against Gram-negative bacteria, serving as a tool for studying insect immunity and chaperone inhibition. | Insect innate immunity, Gram-negative infections, chaperone inhibition, proline-rich peptides, antimicrobial mechanism | Bacterial DnaK chaperone; protein folding inhibition; insect immune pathway activation |
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