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| Product name | CAS:79404-91-4;LY121019 |
| Sequence | |
| Three letter sequence | |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C49H71N7O17 |
| Molecular weight (Da) | 1030.12 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| Cilofungin | #Cilofungin; CAS 79404-91-4; LY121019; Echinocandin B derivative; p-Octyloxybenzoyl echinocandin B | Antifungal peptide, Echinocandin class, β-glucan synthase inhibitor, Cyclic lipopeptide, Candida inhibitor, Cell wall synthesis inhibition, Antifungal drug research | Cyclic hexapeptide: 4,5-Dihydroxy-L-ornithine-Threonine-3-hydroxy-4-methyl-L-proline-3,4-dihydroxy-L-homotyrosine-3-hydroxy-L-proline-Threonine (cyclized) | C₄₉H₇₁N₇O₁₇ | 1029.49 | 1030.13 | N²-p-Octyloxybenzoyl (lipidated) | Cyclized, no free C-terminus | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-CIL001 | White to off-white powder | -20°C, sealed and light-proof, aliquot to avoid repeated freeze-thaw | 2~8°C, use within 1 month, prepare fresh before use | Stable for 48 h at 4°C (in DMSO) | Stable for 2 years at -20°C |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-CIL001 | Cilofungin is a cyclic lipopeptide antifungal agent derived from echinocandin B, specifically inhibits fungal cell wall β-1,3-glucan synthase with potent activity against Candida albicans and Candida tropicalis | Cilofungin (LY121019) is a first-generation semi-synthetic echinocandin cyclic lipopeptide, obtained by enzymatic deacylation of echinocandin B followed by chemical reacylation with p-octyloxybenzoic acid. It specifically inhibits fungal cell wall β-1,3-D-glucan synthase (Fks1/Fks2 complex), blocking β-glucan biosynthesis and causing cell wall structural defects and osmotic lysis. Exhibits potent in vitro antifungal activity against yeasts including Candida albicans and Candida tropicalis, with MIC₉₀ ≤ 0.31 μg/mL. As a classic echinocandin tool compound, it is widely used in fungal cell wall synthesis mechanism studies, antifungal drug screening, Candida infection models and structure-activity relationship research of lipopeptide antibiotics | Antifungal pharmacology, Microbiology, Fungal cell wall synthesis research, Candida infection studies, Lipopeptide antibiotics, Drug screening & SAR, Infection & immunity research | β-1,3-Glucan synthase (1,3-β-D-glucan synthase, Fks1/Fks2) |
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