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| Product name | CAS:1796568-94-9;Goralatide TFA |
| Sequence | Ac-SDKP |
| Three letter sequence | |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C22H34F3N5O11 |
| Molecular weight (Da) | 601.53 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| Goralatide | #Goralatide; CAS 1796568-94-9; Ac-SDKP; Acetyl-Ser-Asp-Lys-Pro tetrapeptide; Hematopoietic progenitor cell cycle inhibitor | Hematopoietic stem/progenitor cell cycle arrest, Antifibrosis, ACE specific substrate, Immune regulation, Angiogenesis, Leukemia hyperthermic purging, Renal/cardiac fibrosis research, Hematopoietic peptide | Acetyl-Ser-Asp-Lys-Pro | C₂₀H₃₃N₅O₉ (free peptide) | 487.23 | 487.51 | Acetylation (Ac-) | Free carboxyl, unmodified | 4 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-GOR001 | White powder | -20°C, sealed and light-proof, aliquot to avoid repeated freeze-thaw | 2~8°C, use within 1 month, prepare fresh & sterile-filter with 0.22μm membrane | Stable for 72 h at 4°C | Stable for 3 years at -20°C |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-GOR001 | Goralatide (Ac-SDKP) is an endogenous bone-marrow derived tetrapeptide, reversibly inhibits hematopoietic progenitor proliferation and exerts potent anti-organ fibrosis activity, specific substrate of ACE, core tool peptide for hematopoiesis and fibrosis pathway research | Goralatide (Ac-SDKP) is an endogenous N-acetylated tetrapeptide isolated from fetal bone marrow, acting as a unique natural specific substrate of Angiotensin-Converting Enzyme (ACE), which degrades and inactivates this peptide. It mediates multiple key physiological effects: 1. Hematopoiesis control: Reversibly arrests hematopoietic pluripotent stem/progenitor cells at G0/G1 cell cycle phase to suppress proliferation, widely used for leukemia hyperthermic purging, hematopoietic transplantation and bone marrow protection models; 2. Broad-spectrum anti-fibrotic activity: Blocks fibroblast activation and excessive collagen deposition to alleviate cardiac, renal and pulmonary fibrotic lesions; 3. Immune & vascular modulation: Inhibits lymphocyte proliferation, regulates angiogenesis and alleviates inflammatory infiltration; 4. RAS pathway balance: Antagonizes Ang II-mediated profibrotic signaling to maintain tissue homeostasis. Widely applied in hematopoietic stem cell biology, organ fibrosis pharmacology, ACE enzyme substrate kinetics, cardiovascular pathology, immune inflammation and hematological transplant preconditioning research | Hematopoietic stem cell biology, Organ fibrosis pharmacology, Cardiovascular pathology, Renin-angiotensin pathway, Leukemia hyperthermic purging, Immune regulation, ACE enzyme kinetics, Antifibrotic peptide drug screening | Angiotensin-Converting Enzyme (ACE, specific substrate); Hematopoietic progenitor cell cycle regulatory cascade; Fibroblast proliferative signaling pathway |
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