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| Description | Citrullinated LL-37 5cit is the fully citrullinated derivative of LL-37 in which all 5 arginine residues (R7, R19, R23, R29, R34) are converted to citrulline: LLGDFF(Cit)KSKEKIGKEFK(Cit)IVQ(Cit)IKDFL(Cit)NLVP(Cit)TES (Sci Rep 2020, PMC7012854), molecular weight ~4498.2 Da, net charge reduced from +6 to +1. Full citrullination essentially abolishes the cationic character of LL-37, greatly weakening its electrostatic interactions with bacterial/viral membranes and significantly reducing its antibacterial and antiviral activities; this modified form is found in neutrophil extracellular traps (NETs) during airway inflammation and is associated with citrullinated LL-37 autoantibody/autoreactive T-cell responses in diseases such as psoriasis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (PMC7345132; PMC12014627). Citrullinated LL-37 5cit is an essential tool for studying the impact of complete citrullination on host defense peptide function and autoimmunity mechanisms. |
| Molecular formula | C₂₀₉H₃₂₈N₅₂O₆₁ (approx.) |
| Molecular weight (Da) | ~4498.2 |
| Structure type | Linear 37-aa peptide (LL-37, all 5 Arg→Cit) |
| Solubility | Soluble in water and PBS |
| Storage | Powder, store dry and protected from light at -20°C |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Citrullinated LL-37 2cit | 2-site hypo-citrullinated LL-37; lightly modified LL-37 | LL-37 modified peptide, immunomodulation, retained antibacterial activity, inflammation regulation, innate immunity research | LL-37 variant with 2 lightly citrullinated arginine residues; mildly reduced positive charge retains most antibacterial activity with fine-tuned immunomodulatory functions | C₂₀₉H₃₆₃N₅₇O₅₁ | 4477.73 | ~4480.0 | Acetate | 37 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-LL37-2C | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot. Avoid repeated freeze-thaw cycles. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in water, dilute acetic acid and PBS. Hypo-citrullination retains most positive charge and antibacterial activity with fine-tuned immune functions. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-LL37-2C | 2-site hypo-citrullinated LL-37 with retained antibacterial activity | Citrullinated LL-37 2cit is the least modified LL-37 variant with 2 citrullinated arginines. Mild charge reduction preserves most antibacterial activity with subtly adjusted immunomodulatory functions, used for studying early effects of citrullination on LL-37 antimicrobial and immune functions. | Innate immunity research, antimicrobial peptide modification, inflammation regulation, LL-37 structure-activity, post-translational modification | Retained antibacterial activity; fine-tuned immune function; low-degree citrullination structure-activity |
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