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| Description | GLK-19 (CAS: 1225014-04-9) is a synthetic antimicrobial peptide de novo designed based on high-frequency amino acid residue statistics from the Antimicrobial Peptide Database (APD2), with the sequence GLKKLLGKLLKKLGKLLLK (19 aa). Molecular formula C₁₀₂H₁₉₄N₂₆O₂₀, molecular weight 2104.79 Da. GLK-19 exhibits an MIC of 10 μM against Escherichia coli, weak activity against MRSA, and outperforms human LL-37 in anti-E. coli activity. The design strategy of GLK-19 demonstrates the methodology of predicting and synthesizing novel AMPs by statistically analyzing amino acid occurrence frequencies from the peptide database, making it a canonical case for studying rational peptide design, database-driven peptide engineering, and low-cost antimicrobial peptide |
| Structure type | Linear 19-mer (de novo designed, Gly-Lys-Leu repeat amphipathic cationic peptide) |
| Solubility | Readily soluble in water, PBS, acetic acid (TFA salt form) |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| GLK-19 | GLK-19 synthetic antimicrobial peptide; Gly-Leu-Lys 19-mer peptide | Antimicrobial peptide, broad-spectrum antibacterial, anti-resistant bacteria, antibiofilm, synthetic peptide | Rationally designed 19-residue cationic antimicrobial peptide rich in glycine, leucine and lysine; forms an amphipathic α-helix with potent membrane-lytic and bactericidal activity | C₉₇H₁₈₅N₃₁O₂₁ | 2080.44 | ~2081.8 | Acetate | 19 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GLK19 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in dilute acetic acid and acidic buffers. Optimized α-helix has strong membrane activity; retains good bactericidal effect under high salt conditions. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GLK19 | GLK-19 synthetic peptide with potent bactericidal activity against resistant bacteria | GLK-19 is a rationally designed 19-residue cationic AMP rich in glycine, leucine and lysine residues, forming a stable amphipathic α-helix. It exerts rapid and potent bactericidal activity against MDR Gram-positive and Gram-negative bacteria, inhibits and eradicates mature biofilms, and has low resistance propensity, serving as a lead for novel antimicrobial drug development. | Synthetic AMPs, resistant bacterial infections, biofilm eradication, peptide antibiotic development, membrane-active peptides | Potent bacterial membrane lysis; biofilm matrix disruption; drug-resistant membrane barrier penetration |
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