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| Description | MDP1 acetate is a 23-residue linear cationic antibacterial peptide engineered from bee-venom melittin, sequence GIGAVLKVLTTGLPALIKRKRQQ. Free-base formula C111H202N34O28, MW 2461.0 Da; acetate C113H206N34O30, MW 2521.05 Da. MDP1 kills bacteria by compromising the membrane integrity of both Gram-positive and Gram-negative organisms, showing potent activity against multidrug-resistant (MDR) S. aureus, E. coli, and P. aeruginosa reference and clinical strains. MDP1 acetate is a tool for melittin-derived membrane-active peptide SAR and anti-MDR membrane-disruption mechanisms. |
| Structure type | Linear 23-mer (melittin-derived amphipathic cationic membrane-disrupting peptide, acetate) |
| Solubility | Readily soluble in water, dilute acetic acid, DMSO |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| MDP1 acetate | MDP acetate; N-acetylmuramyl-L-alanyl-D-isoglutamine acetate; Muramyl Dipeptide acetate; NOD2 agonist; murodase-resistant glycopeptide | NOD2 agonist, innate immune adjuvant, minimal bioactive peptidoglycan motif, glycopeptide, NLRP3 crosstalk, vaccine adjuvant, bacterial cell wall peptidoglycan, acetate salt | Glycopeptide immune agonist, not a conventional peptide - composed of an N-acetylmuramic acid sugar moiety linked to a dipeptide; the sugar is N-acetylmuramic acid (MurNAc), i.e., 2-acetamido-2-deoxy-3-O-(D-1-carboxyethyl)-D-glucopyranose (GlcNAc with a lactic ether at O-3); the lactate carboxyl forms a peptide bond to L-alanine (L-Ala), which in turn links to D-isoglutamine (D-isoGln, the gamma-carboxamide of D-glutamic acid); full structure: N-acetylmuramyl-L-alanyl-D-isoglutamine; one free C-terminal alpha-carboxyl (weakly acidic, on D-isoGln), no free amino group (N-terminus blocked by lactyl group); polyhydroxylated sugar ring confers very high hydrophilicity; no Cys/Met/Trp/Typ oxidation- or light-sensitive residues; acetate counterion present | C21H36N4O13 (acetate); free MDP C19H32N4O11 | 552.23 | 552.53 | Acetate salt; free MDP C19H32N4O11, MW 492.48; acetate counterion C2H4O2 | 2 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-MDP1A-01 | White powder | -20°C, desiccated, sealed; glycopeptide structure is stable, no oxidation/light-sensitive residues, light-insensitive; moderately hygroscopic, must be sealed in a desiccator; aqueous aliquots stable ~6 months at -20°C | 2-8°C, desiccated, for weeks to months | Excellent water solubility (polyhydroxylated sugar ring + polar peptide segment), directly soluble in water or PBS (>=10-50 mg/mL), no DMSO needed; also soluble in DMSO; contains no Cys/Met/Trp sensitive residues, solution is insensitive to oxidation and light; aqueous solutions stable for days at 4°C, aliquot and store at -20°C long-term, avoid repeated freeze-thaw; note that MDP is slowly degraded by mammalian serum enzymes, prepare solutions fresh for experiments | solid is stable; carbohydrate solid is slightly hygroscopic, must be protected from moisture; conventional dry low-temperature storage suffices |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-MDP1A-01 | The minimal immunologically active fragment of bacterial cell wall peptidoglycan (N-acetylmuramyl-L-alanyl-D-isoglutamine), the specific natural ligand of the intracellular NOD2 receptor; activates innate immune signaling and vaccine adjuvanticity; supplied here as the acetate salt. | MDP (Muramyl Dipeptide), N-acetylmuramyl-L-alanyl-D-isoglutamine, is the smallest immunologically active fragment of bacterial cell wall peptidoglycan released after lysozyme and lysosomal enzyme degradation, and was identified in the 1970s as the minimal adjuvant-active structure from Freund's complete adjuvant. Its structure consists of an N-acetylmuramic acid sugar ring (N-acetylglucosamine modified by a lactic ether at O-3) linked via the lactate carboxyl to an L-Ala-D-isoGln dipeptide, representing a conserved motif common to all bacterial peptidoglycan. Upon entering host cells, MDP is recognized by the intracellular receptor NOD2 (nucleotide-binding oligomerization domain-containing protein 2, an NLR family member), which signals through RIP2 kinase to activate NF-kB and MAPK pathways, inducing TNF-alpha, IL-6, IL-1beta and other proinflammatory cytokines and initiating innate immune responses. NOD2 is a major susceptibility gene for Crohn's disease; loss-of-function mutations impair peptidoglycan recognition and are linked to intestinal inflammation and immune dysregulation. MDP also crosstalks with the NLRP3 inflammasome and cGAS-STING pathways, modulating dendritic cell maturation and antigen presentation. As a classic immune adjuvant, MDP and its derivatives (e.g., muramyl tripeptide, Murabutide, Romurtide) are widely used in vaccine research to enhance antigen-specific immunity. This product, as the acetate salt with excellent water solubility, is a standard tool agonist for NOD2 receptor research, innate immune activation, vaccine adjuvant screening, and inflammation model construction. | NOD2 receptor agonist, innate immunity and inflammation, vaccine adjuvant, peptidoglycan immune recognition, Crohn's disease/NOD2-related research, NLRP3 inflammasome crosstalk, glycoimmunology | NOD2 receptor (NLR), RIP2/NF-kB signaling, NLRP3 inflammasome |
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