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| Description | D-K6L9 is a host-defense-like peptide composed of six lysines and nine leucines (K6L9), modified by the inclusion of D-amino acids to improve antimicrobial activity and resistance to degradation by proteases (Isca Biochemicals/MCE). Several L-residues are replaced by their D-enantiomers (Leu-Lys-{d-Leu}-Leu-Lys-{d-Lys}-Leu-{d-Leu}-{d-Lys}-Lys-Leu-Leu-{d-Lys}-Leu-Leu-NH2, 15 aa, C-terminally amidated), conferring stability against degradation by cystic fibrosis (CF) sputum proteases. D-K6L9 shows antimicrobial and antibiofilm activities against multidrug-resistant P. aeruginosa from CF patients without inducing bacterial resistance (J Med Chem 2022); in addition, in animal models it targets and arrests the growth of aggressive, hormone-resistant primary tumors (PMC5542299). Molecular formula C90H174N22O15, molecular weight 1804.48 Da (MCE). Widely used in cystic fibrosis infection therapy, D-peptide design, and antibiofilm research. |
| Molecular formula | C₉₀H₁₇₄N₂₂O₁₅ |
| Molecular weight (Da) | 1804.48 |
| Structure type | Cationic amphipathic α-helical peptide (D-amino-acid-modified) |
| Solubility | Freely soluble in water, PBS, DMSO |
| Storage | -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Syringomycin E | Syringomycin E; Pseudomonas-derived lipopeptide antibiotic | Antifungal lipopeptide, plant disease control, biopesticide, membrane pore-forming agent, phytopathogenic fungi | Lipopeptide antibiotic from Pseudomonas syringae, consisting of a cyclic nonapeptide backbone and a fatty acid side chain; forms ion channels in fungal cell membranes to disrupt membrane potential and integrity, potent against various crop pathogenic fungi | C₅₄H₈₇N₉O₁₇ | 1109.62 | ~1110.4 | Free peptide | 9 (cyclic lipopeptide) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-SYRE | White to off-white crystalline powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in methanol, DMSO and dilute ethanol. Lipopeptide structure is sensitive to strong oxidants; prone to aggregation in aqueous solution. Prepare fresh before use. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-SYRE | Syringomycin E lipopeptide with membrane pore-forming antifungal activity | Syringomycin E is a lipopeptide antibiotic secreted by Pseudomonas syringae, consisting of a cyclic nonapeptide scaffold linked to a fatty acid tail to form an amphipathic structure. It assembles into voltage-gated ion channels in fungal membranes, causing ion leakage and membrane potential collapse, with potent activity against crop pathogenic fungi. | Plant fungal disease control, biopesticide development, lipopeptide antibiotics, membrane channel formation, phytopathology | Fungal membrane ion channel formation; membrane potential collapse; phytopathogen killing |
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