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| Product Name | CAS:63631-40-3: BW-180C |
| Description | BW-180C is a potent and highly selective competitive antagonist of bradykinin B2 receptor. It specifically binds to B2 receptors on cell membranes and blocks various biological effects mediated by endogenous bradykinin, including vasodilation, increased capillary permeability, pain signal transduction and inflammatory mediator release. Modified with unnatural amino acids, its in vivo peptidase resistance is significantly improved, with longer duration of action than native peptide antagonists, and no obvious cross-activity on B1 receptors. It is widely used in bradykinin receptor subtype functional identification, pain conduction mechanism, inflammatory response regulation, cardiovascular pharmacology and allergic disease research, and is a classic tool peptide for bradykinin system research. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Free base molecular formula | C₅₆H₇₅N₁₅O₁₁S |
| Free base molecular weight (Da) | 1162.36, higher for salt form |
| Structure type | Modified nonapeptide with multi-site unnatural amino acid substitution, free peptide / acetate salt |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| BW-180C | BW-180C bradykinin antagonist | Competitive bradykinin B2 receptor antagonist, anti-inflammatory & analgesic, vascular permeability regulation | Modified nonapeptide; multi-site unnatural amino acid substitution based on native bradykinin backbone (D-arginine, hydroxyproline, thienylalanine, etc.), significantly improving receptor affinity and metabolic stability | C₅₆H₇₅N₁₅O₁₁S | 1161.54 | 1162.36 | Free peptide / acetate | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BWC001 | white powder | Store at -20°C, sealed, dry and protected from light. Aliquot to avoid repeated freeze-thaw cycles. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack recommended. | Stable for 7 days at 4°C. Moderate water solubility, assisted by dilute acetic acid or acidic buffer; freely soluble in DMSO. Aqueous solution is susceptible to peptidase degradation; prepare fresh before use. | Stable for 3 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BWC001 | Highly selective competitive B2 receptor antagonist blocks bradykinin-mediated inflammatory pain and vascular effects | BW-180C is a potent and highly selective competitive antagonist of bradykinin B2 receptor. It specifically binds to B2 receptors on cell membranes and reversibly blocks various biological effects mediated by endogenous bradykinin: vasodilation, increased capillary permeability, pain signal transduction, inflammatory mediator release, smooth muscle contraction, etc. Modified with multi-site unnatural amino acids, its in vivo peptidase resistance is significantly improved, with longer duration of action than native peptide antagonists, and no obvious cross-activity on B1 receptors with excellent subtype selectivity. It is widely used in bradykinin receptor subtype functional identification, pain conduction mechanism, inflammatory response regulation, cardiovascular pharmacology and allergic disease research, and is a classic tool peptide for bradykinin system research. | Pain conduction mechanism research, inflammatory response regulation study, bradykinin receptor subtype identification, cardiovascular pharmacology research, allergic disease research | Bradykinin B2 receptor (BDKRB2); Inflammation and pain signaling pathway |
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