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| Description | VT5 (CAS: 352653-12-4) is a 28-amino acid β-sheet-type cell-penetrating peptide with a unique symmetric sequence DPKGDPKGVTVTVTVTVTGKGDPKPD: both N- and C-termini consist of charged DPKGDPKG heptapeptide modules, while the center contains a continuous valine-threonine alternating repeat sequence (VTVTVTVTVT, 10 amino acids). VT5 self-assembles into a β-sheet conformation in aqueous solution, where the valine-threonine repeat sequence forms a hydrophobic β-sheet core, while the charged modules at both ends (containing aspartic acid and lysine) are distributed on the surface providing water solubility and cell-binding capability. This β-sheet amphipathic structure endows VT5 with cell-penetrating ability, achieving transmembrane transport through interactions with cell membranes and conformational changes. The design of VT5 is inspired by the self-assembly properties of natural β-sheet proteins and amyloid peptides, making it an important model for studying β-sheet peptide-membrane interactions, peptide self-assembly, and cell penetration mechanisms. Additionally, the self-assembling properties of VT5 also enable its use in constructing nanofibers, hydrogels, and drug delivery systems, with potential applications in tissue engineering and controlled drug release. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| VT5 | VT5 vascular targeting peptide; tumor vascular targeting pentapeptide | Vascular endothelial targeting peptide, tumor vascular targeting, drug delivery, vascular imaging | Screened 5-mer vascular targeting peptide; specifically binds markers overexpressed on tumor neovascular endothelial cells, mediating targeted enrichment of drugs and imaging agents | C₂₉H₄₆N₈O₇ | 602.35 | ~602.7 | Acetate | 5 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-VT501 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in water, dilute acetic acid and PBS. Optimal receptor binding activity at physiological pH; conformational change and binding activity decrease under strong alkaline conditions. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-VT501 | VT5 pentapeptide specifically targets tumor vascular endothelium for drug & imaging delivery | VT5 is a tumor vascular targeting pentapeptide screened by phage display technology. It specifically binds signature receptors overexpressed on tumor neovascular endothelial cells, mediating targeted enrichment of conjugated chemotherapeutics, imaging agents and nanoparticles in tumor vascular areas, enhancing efficacy and reducing systemic side effects. It is used in tumor vascular targeted therapy, tumor vascular imaging and targeted drug carrier development. | Tumor targeted therapy, vascular targeting drugs, molecular imaging diagnosis, nanomedicine delivery, tumor vasculature research | Tumor vascular endothelial marker; receptor-mediated targeted enrichment; vascular endothelial cell binding site |
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