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| Product name | CAS:651328-78-8;NGR peptide |
| Sequence | CNGRCG |
| Three letter sequence | Cys-Asn-Gly-Arg-Cys-Gly |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C20H36N10O8S2 |
| Molecular weight (Da) | 608.69 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| NGR Peptide CAS 651328-78-8 | #NGR#, CD13 targeting peptide, Tumor neovasculature targeted cyclic peptide, c(CNGRC), Aminopeptidase N ligand | Tumor targeting peptide, CD13 receptor binding, Neovascular targeting, Anti-tumor drug delivery, Tumor imaging probe, Receptor-mediated endocytosis, Nanocarrier modification | Cys-Asn-Gly-Arg-Cys (cyclized via intramolecular disulfide bond) | C₂₀H₃₆N₁₀O₈S₂ | 608.2345 | 608.69 | Unmodified | Free carboxyl group | 5 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-NGR001 | White powder | -20°C, sealed away from light, aliquot under inert gas, avoid repeated freeze-thaw and oxidation | 2-8°C, use within 2 weeks, prepare fresh and protect from light | Stable for 12 h at 4°C under dark condition, prone to oxidative degradation | Stable for 2 years at -20°C under dry, dark, sealed condition |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-NGR001 | 5-residue cyclic c(CNGRC) NGR peptide, specifically binds CD13 aminopeptidase N overexpressed on tumor neovasculature, for targeted delivery of drugs, fluorescent probes and nanoparticles | Cyclic NGR peptide forms rigid conformation via intramolecular disulfide bond of 5 amino acids. The core NGR motif binds with high specificity to Aminopeptidase N (CD13), which is highly expressed on endothelial cells of tumor newborn blood vessels while low-expressed in normal mature vessels, granting excellent tumor vascular selectivity. After receptor binding, it enters cells through endocytosis pathway, and can be conjugated with chemotherapeutics, fluorescent imaging probes, radionuclides, liposomes and nanocarriers. Widely applied in targeted anti-tumor administration, tumor fluorescence/radionuclide imaging, angiogenesis mechanism research, tumor vascular disrupting therapy, peptide-drug conjugate development and in vivo targeted tracing research | Oncopharmacology, Pharmaceutics, Molecular imaging, Vascular biology, Peptide drug delivery, Targeted gene therapy, Nuclear medicine | Aminopeptidase N (CD13/APN), Tumor neovascular endothelial cell membrane |
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