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| Product name | CAS:1480724-61-5:Vosoritide |
| Description | Vosoritide is a sequence‑optimized C‑type natriuretic peptide analog. It selectively activates natriuretic peptide receptor B (NPR‑B), promotes chondrocyte proliferation and differentiation, and stimulates endochondral ossification in the long bone growth plate, thereby promoting long bone growth and improving height growth rate. It has extremely low affinity for NPR‑A receptors and no atrial natriuretic‑like hypotensive and diuretic side effects. It is the first targeted drug for achondroplasia treatment, applied in research fields such as skeletal development disorders, endochondral ossification mechanism, and growth regulatory pathway. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₈₉H₁₄₃N₂₇O₂₈S₂ |
| Molecular weight (Da) | 2164.40 |
| Structure type | Disulfide‑bridged natriuretic peptide analog, sequence optimized |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Cyclization Mode | Length (aa) |
| Vosoritide | Vosoritide; CNP analog; Achondroplasia therapeutic peptide | Promotes long bone growth,Endochondral ossification,High NPR-B selectivity,Achondroplasia study,Growth regulatory peptide,Skeletal development | Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys (disulfide bridged) | C₈₉H₁₄₃N₂₇O₂₈S₂ | 2163.02 | 2164.4 | Intramolecular disulfide bridge | 22 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-VOS001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted. **Strictly prohibited from strong reducing agents** | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 48h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Good water solubility, freely soluble in water and physiological buffer**. Disulfide bond sensitive to strong reducing agents and prone to cleavage and inactivation. Native peptide easily degraded by neutral endopeptidase | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-VOS001 | Highly selective NPR-B agonist that promotes chondrocyte proliferation/differentiation and stimulates long bone growth to improve achondroplasia | Vosoritide is a sequence-optimized C-type natriuretic peptide (CNP) analog. It retains the core receptor-binding ring structure of native CNP while optimizing terminal sequences to improve metabolic stability. It binds with high specificity and affinity to natriuretic peptide receptor B (NPR-B) on chondrocytes of the bone growth plate, activates the intracellular guanylate cyclase domain of the receptor, elevates cGMP levels, and initiates downstream signaling pathways to promote proliferation, differentiation and matrix synthesis of growth plate chondrocytes, accelerates endochondral ossification, and thereby promotes longitudinal growth of long bones. Unlike atrial natriuretic peptide and brain natriuretic peptide, it has almost no affinity for NPR-A receptors, no obvious cardiovascular side effects such as hypotension and diuresis, and strong skeletal growth selectivity. | Achondroplasia study,Skeletal developmental biology,Growth plate regulation,Endochondral ossification mechanism,Natriuretic peptide pathway study,Rare disease drug development | Natriuretic Peptide Receptor B (NPR-B/NPR2); cGMP-mediated chondrocyte differentiation pathway; Endochondral ossification pathway of long bone growth plate |
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