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| Product name | CAS:524060-93-3:Enavermotide |
| Description | Enavermotide is a long-acting motilin receptor agonist. Amino acid modifications enhance metabolic stability. It promotes gastrointestinal smooth muscle contraction and accelerates gastric emptying, and is applied in mechanism research of gastroparesis, functional dyspepsia, gastrointestinal motility disorders and digestive pathways. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular formula | C₁₁₇H₁₇₈N₃₄O₃₇ |
| Theoretical molecular weight (Da) | 2621.87 (subject to actual synthetic batch) |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Enavermotide | Enavermotide; Long-acting motilin agonist; CAS 524060-93-3 | Motilin receptor agonist,Gastroprokinetic effect,Gastroparesis study,Functional dyspepsia study,Long-acting metabolic stability,Gastrointestinal motility regulation | Phenylalanine-valine-proline-isoleucine-phenylalanine-threonine-tyrosine-glycine-glutamic acid-leucine-glutamine-arginine-methionine-glutamine-glutamic acid-lysine-glutamic acid-arginine-asparagine-lysine-glycine-glutamine | C₁₁₇H₁₇₈N₃₄O₃₇ (theoretical) | 2620.31 (theoretical) | 2621.87 (theoretical) | Free amine, amino acid substitution for enzyme resistance | Free carboxyl | 22 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-ENA001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles and strong oxidizing agents | Solid powder stable for 2 years at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Moderate water solubility, dilute acetic acid or small amount of DMSO required for solubilization**. Methionine residue prone to oxidation. Long-chain peptide aqueous solution easily degraded by peptidases with poor room-temperature stability | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ENA001 | Long-acting motilin receptor agonist that promotes gastrointestinal smooth muscle contraction and accelerates gastric emptying, applied in gastric motility disorder research | Enavermotide is a long-acting agonist optimized based on the native motilin backbone. Key site amino acid substitutions enhance enzymatic stability and receptor affinity. It specifically binds to motilin receptors on gastrointestinal smooth muscle and the enteric nervous system, activates GPCR pathways, increases intracellular calcium concentration, induces rhythmic contraction of gastrointestinal smooth muscle, and accelerates gastric emptying and small intestinal transit. Its metabolic stability is significantly superior to native motilin with longer duration of action and no obvious central side effects. It serves as a mechanism research tool for gastrointestinal motility disorders such as gastroparesis, functional dyspepsia and postoperative ileus, and also as a core lead molecule for the development of novel gastroprokinetic drugs. | Gastroparesis research,Functional dyspepsia study,Gastrointestinal motility regulation study,Postoperative ileus research,Digestive physiology study,Gastroprokinetic drug development | Motilin Receptor (MTLR); Gastrointestinal smooth muscle contraction pathway; Calcium signaling regulatory pathway |
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