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| Product Name | CAS:152074-97-0:Dirucotide |
| Description | Dirucotide (MBP 8298) is a native 17-mer peptide fragment of human myelin basic protein, corresponding to the MBP amino acid sequence 83-99. It induces immune tolerance in myelin-specific autoreactive T cells, reduces autoimmune attack on central nervous system myelin, and delays the progression of multiple sclerosis. Applied in autoimmune demyelinating diseases, immune tolerance mechanism and peptide vaccine research. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Structure type | Native myelin protein-derived linear 17-mer peptide, no chemical modification |
| Molecular Weight (Da) | ~1960 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Length (aa) |
| Dirucotide | Dirucotide; MBP 8298; Myelin basic protein peptide; CAS 152074-97-0 | Immune tolerance induction,Multiple sclerosis study,Myelin protection,Autoimmune disease,T cell epitope peptide,Peptide vaccine | Aspartic acid-glutamic acid-asparagine-proline-valine-valine-histidine-phenylalanine-phenylalanine-lysine-asparagine-isoleucine-valine-threonine-proline-arginine-threonine | Large polypeptide, no precise small-molecule formula; subject to actual batch MS | - | ~1960 (theoretical) | Free amine, no modification | Free carboxyl, no modification | 17 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-DRC001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 1 year at 2-8℃ sealed & dry; prepare aqueous solutions freshly before use | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Good water solubility, freely soluble in water and physiological buffer**. Unmodified native long peptide easily degraded by peptidases with rapid activity decay at room temperature. Histidine and tyrosine prone to photooxidation | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-DRC001 | Native myelin basic protein 17-mer peptide that induces autoimmune tolerance and delays demyelination progression in multiple sclerosis | Dirucotide is a native T cell epitope peptide derived from human myelin basic protein (MBP), corresponding to the immunodominant epitope at positions 83-99 of the MBP molecule. After uptake by antigen-presenting cells, it is presented to autoreactive CD4+ T cells via MHC class II molecules, inducing T cell anergy, apoptosis or conversion to regulatory T cells, establishing immune tolerance to myelin antigens, thereby reducing T cell-mediated central nervous system myelin damage and demyelinating lesions, and delaying the progression of multiple sclerosis. This peptide is a native endogenous protein fragment with mild immunogenicity and no obvious toxic side effects. It serves as a core tool molecule for multiple sclerosis immunotherapy research, autoimmune tolerance mechanism analysis, myelin antigen epitope identification, and peptide vaccine SAR optimization. | Multiple sclerosis research,Autoimmune disease study,Immune tolerance mechanism,Demyelinating disease study,T cell epitope research,Peptide vaccine development | MHC class II molecule-peptide complex; Myelin-specific autoreactive T cells; Central immune tolerance regulatory pathway |
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