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| Product Name | CAS:251579-55-2:ABT-510 |
| Description | ABT-510 is a synthetic nonapeptide optimized based on the active sequence of thrombospondin-1 (TSP-1). It specifically binds to CD36 receptors on endothelial cell surfaces, induces endothelial cell apoptosis, inhibits proliferation and migration, and blocks neovascularization, thereby inhibiting solid tumor growth and metastasis. Applied in tumor anti-angiogenesis mechanism research and peptide drug development. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular Formula | C₄₂H₇₀N₁₀O₁₀ |
| Molecular Weight (Da) | 859.08 |
| Terminal modifications | N-terminal acetylation, C-terminal amidation, with D-amino acids and unnatural amino acids |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Length (aa) |
| ABT-510 | ABT-510; TSP-1 mimetic peptide; Anti-angiogenic nonapeptide; CAS 251579-55-2 | CD36 receptor agonism,Anti-angiogenesis,Endothelial cell inhibition,Solid tumor research,Tumor metastasis inhibition,Peptide drug development | Acetyl-glycine-valine-D-alloisoleucine-threonine-norvaline-valine-glycine-arginine-prolinamide | C₄₂H₇₀N₁₀O₁₀ | 858.52 | 859.08 | Acetylation, no free amine | Amidation | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-ABT001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 2 years at 2-8℃ sealed & dry; stock solutions require small amount of DMSO for solubilization | Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Limited water solubility, small amount of DMSO or dilute acetic acid required for solubilization**. D-amino acids and terminal modifications significantly enhance enzymatic resistance. Hydrophobic side chains tend to cause aggregation | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ABT001 | TSP-1 mimetic anti-angiogenic nonapeptide that agonizes CD36 receptors to induce endothelial cell apoptosis and inhibit tumor neovascularization | ABT-510 is a synthetic peptide mimicking the active site of thrombospondin-1 (TSP-1) type I repeat sequence. Introduction of unnatural amino acids such as D-alloisoleucine and norvaline, as well as terminal modifications, significantly improves metabolic stability and receptor affinity. It specifically binds to CD36 receptors on microvascular endothelial cell surfaces, activates downstream caspase apoptotic pathways, induces activated endothelial cell apoptosis, and simultaneously inhibits endothelial cell proliferation, migration and tube formation, thereby blocking tumor neovascularization, cutting off tumor nutrient supply, and inhibiting solid tumor growth and metastasis. This molecule has clear anti-angiogenic activity with no obvious systemic toxic side effects. It serves as a core tool peptide for tumor angiogenesis mechanism research, anti-angiogenic peptide drug screening, and CD36 receptor functional identification. | Solid tumor research,Anti-angiogenesis study,Endothelial cell biology,CD36 receptor function,Tumor metastasis study,Peptide drug development | Cluster of Differentiation 36 (CD36); Endothelial cell apoptosis pathway; Neovascularization inhibitory pathway |
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