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| Product name | CAS:159776-69-9:Cemadotin |
| Description | Cemadotin is a synthetic optimized analog of dolastatin 15, a peptidic microtubule polymerization inhibitor. It binds to tubulin to block cell mitosis and induce tumor cell apoptosis, with potent cytotoxic activity against various solid tumors and hematological malignancies. Applied in antitumor mechanism research and cytotoxic drug screening. |
| Purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₃₉H₅₇N₅O₆ |
| Molecular weight (Da) | 691.91 |
| Structure type | Synthetic modified pentapeptide analog with multiple unnatural amino acids |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Structure Type | Cytotoxicity |
| Cemadotin | Cemadotin; LU-103793; Dolastatin analog; CAS 159776-69-9 | Microtubule polymerization inhibition,Antimitotic,Broad-spectrum cytotoxicity,Solid tumor research,Hematological malignancy study,Antitumor drug screening | Pentapeptide backbone modified derivative with unnatural structures such as N,N-dimethylvaline and dolaproine | C₃₉H₅₇N₅O₆ | 691.43 | 691.91 | Synthetic peptidic small-molecule derivative | Potent cytotoxicity |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-CMD001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid high temperature and moisture | Solid powder stable for 1 year at 2-8℃ sealed and dry; stock solutions must be prepared in DMSO | Stable for 72 h at 4℃ in dark; stable for 1 month at -20℃ in aliquots. **Extremely poor water solubility, DMSO required for solubilization**. Molecular structure is sensitive to light and heat, easily degraded and inactivated. Strong cytotoxicity; handle with proper protection | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CMD001 | Dolastatin-class peptide derivative, potent microtubule inhibitor that blocks mitosis and induces tumor cell apoptosis | Cemadotin is a synthetic peptidic cytotoxic drug optimized based on natural dolastatin 15. Structural modifications retain microtubule binding activity while improving chemical stability and druggability. It specifically binds to the vinblastine binding site of tubulin, inhibits tubulin polymerization, disrupts spindle formation, arrests cell cycle at G2/M phase, and ultimately induces tumor cell apoptosis. This molecule exhibits nanomolar potent cytotoxic activity against various solid tumors such as breast cancer, lung cancer and colon cancer, as well as leukemia and lymphoma, and is also effective on multidrug-resistant tumor cells. It serves as a classic tool compound for antitumor mechanism research, cell cycle regulation analysis, and novel microtubule inhibitor drug screening. | Solid tumor research,Hematological malignancy study,Cell cycle research,Microtubule dynamics study,Antitumor drug screening,Multidrug resistance research | Tubulin vinblastine binding site; Cell mitosis blockade pathway; G2/M phase cell cycle arrest and apoptosis pathway |
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