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| Product name | CAS:848084-83-3:Tigapotide |
| Description | Tigapotide (development code PCK3145) is a prostate cancer-targeted synthetic nonapeptide. It specifically induces apoptosis of prostate cancer cells, inhibits tumor proliferation and metastasis, and is applied in castration-resistant prostate cancer, solid tumor apoptosis mechanism and antitumor peptide drug development. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular formula | C₅₄H₇₃N₁₃O₁₄ |
| Theoretical molecular weight (Da) | 1128.24 (subject to actual synthetic batch) |
| Terminal modifications | Native free termini |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Tigapotide | Tigapotide; PCK3145; CAS 848084-83-3; Prostate cancer apoptotic peptide | Prostate cancer targeting,Pro-apoptotic effect on tumor cells,Proliferation and metastasis inhibition,Castration-resistant prostate cancer study,Solid tumor research,Antitumor peptide | Asparagine-glutamine-tryptophan-phenylalanine-glutamine-leucine-methionine-asparagine-arginine | C₅₄H₇₃N₁₃O₁₄ (theoretical) | 1127.54 | 1128.24 | Free amine, no modification | Free carboxyl, no modification | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-TGP001 | white powder | Store at -20℃, sealed, dry & protected from light, stored under nitrogen in aliquots; avoid repeated freeze-thaw cycles and strong oxidizing agents | Solid powder stable for 2 years at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. Limited water solubility, small amount of DMSO or dilute acetic acid required for solubilization**. Methionine and tryptophan residues prone to oxidative inactivation, isolate from air and strong light | Stable for 3 years at -20℃ under dry, dark & nitrogen atmosphere |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-TGP001 | Prostate cancer-targeted nonapeptide that specifically induces tumor cell apoptosis and inhibits proliferation and metastasis | Tigapotide is a synthetic nonapeptide antitumor drug candidate screened from prostate-related proteins. It specifically recognizes surface receptors on prostate cancer cells, rapidly enters cells to activate the mitochondrial apoptosis pathway, upregulates pro-apoptotic protein Bax expression, downregulates anti-apoptotic protein Bcl-2 level, and induces caspase cascade to trigger tumor cell apoptosis. It also inhibits tumor cell invasion and metastasis ability and downregulates matrix metalloproteinase expression. This molecule exhibits significant activity against castration-resistant prostate cancer cells with low toxicity to normal cells, and has entered preclinical and early clinical research stages for prostate cancer. It serves as a core tool molecule for solid tumor apoptosis mechanism research, antitumor peptide drug development, and prostate cancer targeted therapy research. | Prostate cancer research,Castration-resistant prostate cancer study,Tumor apoptosis mechanism study,Solid tumor therapy research,Antitumor peptide development,Tumor metastasis inhibition research | Mitochondrial apoptosis pathway; Caspase cascade reaction; Tumor cell invasion and metastasis regulatory pathway |
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