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| Product name CAS:166089‑33‑4 | Nagrestipen |
| Description | Nagrestipen is a novel cyclic lipopeptide antibiotic that exerts rapid bactericidal effect by inserting into bacterial cell membranes and disrupting their integrity. It exhibits potent activity against multidrug‑resistant Gram‑positive bacteria such as MRSA and VRE. Applied in drug‑resistant infection, antibacterial mechanism and novel antibiotic development research. |
| Purity (HPLC, %) | 90%/95%/98% |
| Theoretical molecular weight | ~1.6 kDa |
| Structure type | Cyclic lipopeptide with fatty acid side chain modification |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Cyclization Mode | Sequence Length (aa) |
| Nagrestipen | Nagrestipen; Cyclic lipopeptide antibiotic; CAS 166089-33-4 | Anti-multidrug-resistant bacteria,Rapid bactericidal effect,Membrane disruption mechanism,MRSA/VRE activity,Cyclic lipopeptide class,Novel antibiotic | Cationic cyclic peptide backbone with N-terminal conjugated long-chain fatty acid | Large cyclic lipopeptide, no precise small-molecule formula; subject to actual batch MS | - | ~1600 (theoretical) | Amide bond cyclization | ~10 (core peptide + fatty acid side chain) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-NAG001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid high temperature and humidity | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions prepared in DMSO or methanol | Stable for 72 h at 4℃ under anhydrous conditions. Prone to aggregation in aqueous phase; **aqueous solutions must be prepared freshly before use**. **Poor water solubility, DMSO required for solubilization**. Fatty acid side chain tends to cause aqueous phase aggregation. Sensitive to high temperature and acid/base, easily degraded and inactivated | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-NAG001 | Novel cationic cyclic lipopeptide antibiotic that disrupts bacterial cell membranes for rapid bactericidal effect, potent against multidrug-resistant Gram-positive bacteria | Nagrestipen is a new-generation cyclic lipopeptide antimicrobial compound composed of a cyclic cationic peptide backbone and a long-chain fatty acid side chain, with a mechanism similar to daptomycin but structurally optimized. Its cationic region binds to negatively charged phospholipids on bacterial surfaces, and the fatty acid side chain inserts into the cell membrane phospholipid bilayer, aggregates to form pores, disrupts cell membrane integrity and membrane potential, leading to intracellular substance leakage and rapid bacterial killing. This molecule exhibits potent bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus and Enterococcus, and is also effective against multidrug-resistant strains such as MRSA and VRE, with low cross-resistance. It serves as a core tool molecule for drug-resistant infection mechanism research, novel membrane-targeted antibiotic development, and antimicrobial peptide structure-activity relationship analysis. | Drug-resistant infection research,Novel antibiotic development,Bacterial membrane biology study,MRSA/VRE research,Antibacterial mechanism study,Infection immunity research | Bacterial cell membrane phospholipid bilayer; Membrane potential disruption and pore formation; Rapid bactericidal pathway against Gram-positive bacteria |
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