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| Product name | CAS:17034‑35‑4:Secretin (swine) |
| Description | Secretin is a classic gastrointestinal hormone secreted by duodenal S cells. It specifically binds secretin receptors on pancreatic duct epithelial cells, stimulates the pancreas to secrete large amounts of bicarbonate‑rich pancreatic juice to neutralize gastric acid entering the duodenum, while inhibiting gastrin release and gastric emptying, and regulating bile secretion and gastrointestinal motility. Porcine secretin is highly homologous to human physiological activity, and serves as a classic tool peptide for pancreatic function testing, gastrointestinal physiology research, and mechanism study of pancreatic insufficiency diseases. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₁₃₀H₂₂₀N₄₄O₄₁ |
| Molecular weight (Da) | 3059.42 |
| Structure type | Native linear 27‑mer, C‑terminal amidated, unmodified |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Terminal Modification | Length (aa) |
| Secretin (swine) | Secretin (swine); Secretin porcine | Pancreatic secretion stimulation, Gastric acid neutralization, Pancreatic function test, Gastrointestinal hormone, Pancreatic function study, Native gastrointestinal peptide | His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH₂ | C₁₃₀H₂₂₀N₄₄O₄₁ | 3057.62 | 3059.42 | C-terminal amidated, N-terminal free | 27 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-SEC001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 48 h at 4℃; easily degraded by peptidases at room temperature with rapid activity decay,**Good water solubility, freely soluble in neutral physiological buffer**. Native unmodified linear long peptide, easily degraded by aminopeptidases and endopeptidases | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-SEC001 | Native gastrointestinal hormone that specifically stimulates pancreatic secretion of bicarbonate-rich juice, neutralizes gastric acid and regulates gastrointestinal function | Secretin is the first discovered gastrointestinal hormone, mainly synthesized and secreted by S cells in the upper duodenum under gastric acid stimulation. It binds to G protein-coupled secretin receptors on pancreatic duct epithelial cells, activates the cAMP/PKA signaling pathway, and stimulates ductal epithelial cells to secrete large amounts of water and bicarbonate, diluting and neutralizing gastric acid entering the duodenum to provide a suitable weakly alkaline environment for pancreatic enzyme digestion. Meanwhile, it inhibits gastrin release and gastric acid secretion, slows gastric emptying, regulates bile secretion and intestinal motility, and synergistically maintains gastrointestinal digestive homeostasis. Porcine secretin is highly homologous to human biological activity, serving as a classic reagent for clinical pancreatic function stimulation tests and a standard tool peptide for gastrointestinal physiology and pancreatic disease research. | Pancreatic function testing, Gastrointestinal physiology study, Pancreatic insufficiency, Gastric acid-related diseases, Bile secretion regulation, Gastrointestinal hormone pathway | Secretin Receptor (SCTR); cAMP/PKA signaling pathway; Pancreatic bicarbonate secretion and gastrointestinal homeostasis regulatory pathway |
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