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| Product name | CAS:910463-68-2; Semaglutide |
| Sequence | H-{Aib}-EGTFTSDVSSYLEGQAA-{C18 diacid-γ-Glu-(AEEA)2-Lys}-EFIAWLVRGRG |
| Three letter sequence | |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C187H291N45O59 |
| Molecular weight (Da) | 4113.58 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| Semaglutide | #Semaglutide; CAS 910463-68-2; Long-acting GLP-1 peptide; GLP-1 receptor agonist | GLP-1 receptor agonist, Long-acting hypoglycemic & weight-loss, Lipidated modification, Albumin binding, Type 2 diabetes, Obesity metabolism, Appetite suppression, Insulinotropic, Gastric emptying regulation | His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(γ-Glu-octadecanedioic acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly | C₁₈₇H₂₉₁N₄₅O₅₉ | 4113.17 | 4114.58 | Free amine, unmodified | Free carboxyl, unmodified | 31 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-SEMA001 | White powder | -20°C, sealed and light-proof, aliquot to avoid repeated freeze-thaw | 2~8°C, use within 1 month, prepare fresh and sterile-filter via 0.22μm membrane | Stable for 48 h at 4°C | Stable for 3 years at -20°C |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-SEMA001 | Semaglutide is a long-acting lipidated GLP-1 analog with high GLP-1 receptor affinity, potent hypoglycemic and appetite-suppressing weight-loss effects for type 2 diabetes & obesity metabolism research | Semaglutide is a 31-amino-acid long-acting peptide engineered from native human GLP-1, two core modifications enhance metabolic stability: Ala8 replaced by Aib to resist DPP4 degradation; Lys20 side chain conjugated with γ-glutamate-octadecanedioic acid lipid tail, enabling reversible serum albumin binding and extending in-vivo half-life over 7 days. It activates GLP-1 receptors in pancreatic islets, central nervous system and peripheral tissues: 1. Glycemic control: Stimulates glucose-dependent insulin secretion and suppresses glucagon release to smooth postprandial glucose; 2. Metabolic weight loss: Central inhibition of hunger signals, delayed gastric emptying and reduced calorie intake, lowering visceral fat mass; 3. Cardiorenal protection: Improves endothelial function, reduces albuminuria and regulates lipid profile. Widely applied in type 2 diabetes, obesity, NAFLD/NASH, cardiometabolic disease, GLP-1 GPCR pharmacology and long-acting peptide formulation development | Metabolic endocrinology, Diabetic pharmacology, Obesity weight-loss model, NAFLD/NASH research, Cardiometabolism, GPCR signaling pathway, Long-acting peptide drug, Feeding behavior regulation | GLP-1 Receptor GLP1R (Class B G protein-coupled receptor) |
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