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| Product name | CAS:174630‑04‑7:Reversin 121 |
| Description | Reversin 121 is a highly active small‑molecule inhibitor of P‑glycoprotein. It specifically binds to P‑gp transporters highly expressed on tumor cell membranes, inhibits its ATP‑dependent drug efflux function, significantly increases the intracellular accumulation of chemotherapeutic drugs such as doxorubicin and paclitaxel, reverses the multidrug resistance phenotype, and enhances the cytotoxicity of chemotherapeutic drugs. It has strong reversal activity and weak off‑target effects, and is a classic tool compound for tumor multidrug resistance mechanism research and chemosensitizing drug development. |
| Purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₂₁H₂₀O₆ |
| Molecular weight (Da) | 368.38 |
| Structure type | Small‑molecule flavonoid organic compound, non‑peptide |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Product Attribute | Target |
| Reversin 121 | Reversin 121; P-gp inhibitor 121 | Multidrug resistance reversal, P-gp inhibition, Chemosensitization, Tumor drug resistance research, Small-molecule inhibitor, Non-peptide | Flavonoid parent nucleus with side-chain modified P-gp binding domain | C₂₁H₂₀O₆ | 368.13 | 368.38 | Non-peptide small molecule | P-glycoprotein (P-gp) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| SML-REV121 | Yellow to orange-yellow crystalline powder | Store at -20℃, sealed, dry, protected from light, nitrogen-protected, aliquoted; avoid repeated freeze-thaw cycles | Stable for 1 month at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 7 days at 4℃ under anhydrous conditions; easy to precipitate in aqueous solution, prepare freshly before use**Poor water solubility, requires organic solvents such as DMSO and DMF, extremely easy to precipitate in physiological buffer**. Small-molecule flavonoids prone to photodegradation and oxidation | Stable for 2 years at -20℃ under dry, oxygen-free and light-proof conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| SML-REV121 | Highly selective small-molecule P-gp inhibitor that reverses tumor multidrug resistance and significantly enhances chemotherapeutic cytotoxicity | Reversin 121 inhibits the ATP hydrolase activity of P-glycoprotein by binding to its nucleotide-binding domain, blocks the ATP-dependent drug efflux process, thereby reduces the efflux of chemotherapeutic drugs by tumor cells, increases intracellular drug concentration, and restores the sensitivity of drug-resistant cells to chemotherapeutic drugs. It has high selectivity for P-gp, weak effect on other ABC transporters such as MRP and BCRP, and lower off-target toxicity. It is a core tool compound for studying ABC transporter function, tumor multidrug resistance mechanism and chemosensitization strategies. | Tumor multidrug resistance, ABC transporter function, Chemosensitization research, Tumor pharmacology, Drug resistance mechanism validation, Small-molecule drug development | P-glycoprotein (P-gp/ABCB1); ATP-dependent drug efflux pathway; Multidrug resistance reversal pathway |
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