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| Product name | CAS 1997361‑85‑9 Semaglutide acetate |
| Sequence | His‑Aib‑Glu‑Gly‑Thr‑Phe‑Thr‑Ser‑Asp‑Val‑Ser‑Ser‑Tyr‑Leu‑Glu‑Gly‑Gln‑Ala‑Ala‑Lys(C18 diacid‑γ‑Glu‑(AEEA)₂)‑Glu‑Phe‑Ile‑Ala‑Trp‑Leu‑Val‑Arg‑Gly‑Arg‑Gly |
| Three letter sequence | H‑His‑Aib‑Glu‑Gly‑Thr‑Phe‑Thr‑Ser‑Asp‑Val‑Ser‑Ser‑Tyr‑Leu‑Glu‑Gly‑Gln‑Ala‑Ala‑Lys(C18 diacid‑γ‑Glu‑(AEEA)₂)‑Glu‑Phe‑Ile‑Ala‑Trp‑Leu‑Val‑Arg‑Gly‑Arg‑Gly‑OH |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₁₈₉H₂₉₅N₄₅O₆₁ |
| Molecular weight (Da) | 4173.69 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| Semaglutide acetate | Semaglutide acetate; CAS 1997361-85-9 (free base); Long-acting GLP-1 analog | GLP-1 receptor agonist,Long-acting anti-diabetic peptide,Anti-obesity,Appetite regulation,Metabolic disorder research,GPCR tool peptide | Histidine-2-aminoisobutyric acid-Glutamic acid-Glycine-Threonine-Phenylalanine-Threonine-Serine-Aspartic acid-Valine-Serine-Serine-Tyrosine-Leucine-Glutamic acid-Glycine-Glutamine-Alanine-Alanine-Lysine[Nε-C18 diacid-γ-Glutamic acid-(AEEA)₂]-Glutamic acid-Phenylalanine-Isoleucine-Alanine-Tryptophan-Leucine-Valine-Arginine-Glycine-Arginine-Glycine | C₁₈₉H₂₉₅N₄₅O₆₁ (monoacetate) | 4170.18 | 4173.69 | Free amine, unmodified | Free carboxyl, unmodified | 31 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-SEMA001 | White powder | Store at -20℃, protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles and moisture | Solid powder stable for 2 years sealed and dry at 2-8℃; prepare aqueous solutions freshly before use, aliquots stable for 1 month at -20℃; 0.1% BSA is recommended to extend stability | Stable for 72 h at 4℃; avoid repeated freeze-thaw cycles | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-SEMA001 | Long-acting highly selective GLP-1 receptor agonist; glucose-dependent glycemic control, appetite suppression, gastric emptying delay, weight loss and cardiometabolic benefits | Semaglutide acetate is a long-acting modified analog of human glucagon-like peptide-1 (GLP-1). It shows high selectivity for GLP-1 receptor with no significant binding affinity for GIP or glucagon receptors. The Aib substitution at position 2 confers remarkable resistance to dipeptidyl peptidase-4 (DPP-4) proteolysis. A C18 fatty diacid side chain is covalently conjugated to the ε-amino group of Lys20, enabling reversible serum albumin binding and greatly prolonged in vivo half-life, providing a structural basis for long-acting formulation development. It promotes insulin secretion and suppresses glucagon release in a glucose-dependent manner to stabilize glycemic fluctuations. It also delays gastric emptying and reduces central appetite signaling to decrease food intake and achieve weight loss. In addition, it exhibits activities including improved lipid profile, reduced vascular inflammation and ameliorated hepatic lipid metabolism to slow MASLD progression. It is widely adopted for pharmacological research and innovative peptide drug development targeting type 2 diabetes, obesity, metabolic associated liver disease and cardiovascular protection. | Diabetes pharmacology research,Obesity and metabolic disease research,Anti-diabetic peptide drug development,MASLD research,Cardiovascular pharmacology research,GPCR signaling pathway research | Glucagon-like peptide-1 receptor (GLP-1R); cAMP/PKA signaling pathway |
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